2. Anti-infection Epigenetics
  3. SARS-CoV Histone Methyltransferase DNA Methyltransferase
  4. SARS-CoV-2 nsp14-IN-1

SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2 Nsp14 MTase with an IC50 value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases.

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SARS-CoV-2 nsp14-IN-1 Chemical Structure

SARS-CoV-2 nsp14-IN-1 Chemical Structure

CAS No. : 2816165-02-1

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SARS-CoV-2 nsp14-IN-1 Related Antibodies

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Description

SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2 Nsp14 MTase with an IC50 value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases[1].

IC50 & Target

IC50：0.061 μM (Nsp14 MTase) [1]
In Vitro

SARS-CoV-2 nsp14-IN-1 (Compound 3) displays an excellent selectivity profile for Nsp14 MTase With an IC50 value of 0.061 μM.
SARS-CoV-2 nsp14-IN-1 (Compound 3) shows low passive diffusion rates in PAMPA.
SARS-CoV-2 nsp14-IN-1 (Compound 3) does not suffer major metabolic liabilities in human plasma and liver S9 fractions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2 nsp14-IN-1 Related Antibodies
Molecular Weight

456.48

Formula

C20H20N6O5S
CAS No.
SMILES

O=S(C1=CC=C2C=CC=CC2=C1)(NC[C@H]3O[C@@H](N4C=NC5=C(N)N=CN=C45)[C@H](O)[C@@H]3O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SARS-CoV-2 nsp14-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2 nsp14-IN-12816165-02-1 SARS-CoVHistone MethyltransferaseDNA MethyltransferaseSARS coronavirusDNMTsDNA MTasesSARS-CoV-2Nsp14bisubstrate inhibitormethyltransferase inhibitorantiviralInhibitorinhibitorinhibit

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