SARS-CoV-2 nsp14-IN-1
SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2 Nsp14 MTase with an IC50 value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases.
For research use only. We do not sell to patients.
- CAS No.: 2816165-02-1
- Formula: C20H20N6O5S
- Molecular Weight:456.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50：0.061 μM (Nsp14 MTase) [1]
SARS-CoV-2 nsp14-IN-1 (Compound 3) displays an excellent selectivity profile for Nsp14 MTase With an IC50 value of 0.061 μM.
SARS-CoV-2 nsp14-IN-1 (Compound 3) shows low passive diffusion rates in PAMPA.
SARS-CoV-2 nsp14-IN-1 (Compound 3) does not suffer major metabolic liabilities in human plasma and liver S9 fractions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2816165-02-1
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Molecular Weight 456.48
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Formula C20H20N6O5S
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SMILES
O=S(C1=CC=C2C=CC=CC2=C1)(NC[C@H]3O[C@@H](N4C=NC5=C(N)N=CN=C45)[C@H](O)[C@@H]3O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2 nsp14-IN-1 Related Classifications
HY-150680 Related Classifications
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