2816165-02-1
Chemical Structure
SARS-CoV-2 nsp14-IN-1
- CAS No.: 2816165-02-1
- Formula:C20H20N6O5S
- Molecular Weight:456.48
IUPAC Name: N-(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)naphthalene-2-sulfonamide
InChIKey: LQKQDYIGEWTUDG-WVSUBDOOSA-N
SMILES: O=S(C1=CC=C2C=CC=CC2=C1)(NC[C@H]3O[C@@H](N4C=NC5=C(N)N=CN=C45)[C@H](O)[C@@H]3O)=O
Biological Activity: SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2 Nsp14 MTase with an IC50 value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases[1].
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SARS-CoV-2 nsp14-IN-1 | SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2 Nsp14 MTase with an IC50 value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases. | |||||||||||||||||||||
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