SARS-CoV-2-IN-14
Based on 1 Customer Validation
SARS-CoV-2-IN-14 (compound 6) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.39 μM. SARS-CoV-2-IN-14 is a niclosamide analogue. SARS-CoV-2-IN-14 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally.
For research use only. We do not sell to patients.
- Purity: 99.02%
- CAS No.: 22203-98-1
- Formula: C13H9Cl2NO2
- Molecular Weight:282.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1.65 μM
Compound: 14
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Inhibition of Wnt/beta-catenin in HEK293 cells assessed as inhibition of Wnt3A-stimulated TOPFlash activity after 8 hrs
Inhibition of Wnt/beta-catenin in HEK293 cells assessed as inhibition of Wnt3A-stimulated TOPFlash activity after 8 hrs
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[PMID: 26272032] |
| J774.A1 | CC50 |
50.53 μM
Compound: 32
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Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability by MTT assay
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[PMID: 36565533] |
| Vero | CC50 |
13.87 μM
Compound: 32
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by MTT assay
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[PMID: 36565533] |
| Vero C1008 | CC50 |
100 μM
Compound: 6
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability preincubated for 2 hrs followed by SARS-CoV-2 addition measured after 24 hrs by CPE assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability preincubated for 2 hrs followed by SARS-CoV-2 addition measured after 24 hrs by CPE assay
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[PMID: 35344901] |
| Vero C1008 | CC50 |
2.46 μM
Compound: 6
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Cytotoxicity against African Green monkey Vero E6 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against African Green monkey Vero E6 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 35344901] |
Chemical Information
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CAS No. 22203-98-1
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Appearance Solid
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Molecular Weight 282.12
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Formula C13H9Cl2NO2
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Color White to off-white
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SMILES
O=C(C1=C(C=CC(Cl)=C1)O)NC2=CC(Cl)=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (886.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5446 mL | 17.7230 mL | 35.4459 mL | 88.6148 mL |
| 5 mM | 0.7089 mL | 3.5446 mL | 7.0892 mL | 17.7230 mL | |
| 10 mM | 0.3545 mL | 1.7723 mL | 3.5446 mL | 8.8615 mL | |
| 15 mM | 0.2363 mL | 1.1815 mL | 2.3631 mL | 5.9077 mL | |
| 20 mM | 0.1772 mL | 0.8861 mL | 1.7723 mL | 4.4307 mL | |
| 25 mM | 0.1418 mL | 0.7089 mL | 1.4178 mL | 3.5446 mL | |
| 30 mM | 0.1182 mL | 0.5908 mL | 1.1815 mL | 2.9538 mL | |
| 40 mM | 0.0886 mL | 0.4431 mL | 0.8861 mL | 2.2154 mL | |
| 50 mM | 0.0709 mL | 0.3545 mL | 0.7089 mL | 1.7723 mL | |
| 60 mM | 0.0591 mL | 0.2954 mL | 0.5908 mL | 1.4769 mL | |
| 80 mM | 0.0443 mL | 0.2215 mL | 0.4431 mL | 1.1077 mL | |
| 100 mM | 0.0354 mL | 0.1772 mL | 0.3545 mL | 0.8861 mL |
SARS-CoV-2-IN-14 Related Classifications
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