SARS-CoV-2 nsp14-IN-2
SARS-CoV-2 nsp14-IN-2 is a potent SARS-CoV-2 Nsp14 methyltransferase inhibitor with an IC50 value of 0.093 µM. SARS-CoV-2 nsp14-IN-2 shows antiviral activity. SARS-CoV-2 nsp14-IN-2 shows plasma and liver S9 stability. SARS-CoV-2 nsp14-IN-2 has the potential for the research of COVID-19.
For research use only. We do not sell to patients.
- CAS No.: 2816165-16-7
- Formula: C21H21N5O5S
- Molecular Weight:455.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.093 µM (SARS-CoV-2 Nsp14 methyltransferase)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>100 μM
Compound: 10
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Cytotoxicity against human A549 cells overexpressing ACE2 and TMPRSS2 incubated for 48 hrs by MTS assay
Cytotoxicity against human A549 cells overexpressing ACE2 and TMPRSS2 incubated for 48 hrs by MTS assay
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[PMID: 36097498] |
SARS-CoV-2 nsp14-IN-2 (compound 10) (0-100 µM) shows antiviral activity with an EC50 value of 0.72 µM and CC50 value of >100 µM[1].
SARS-CoV-2 nsp14-IN-2 (24 h) shows plasma stability with t1/2s of >24, >24 h for human and mouse, respectively[1].
SARS-CoV-2 nsp14-IN-2 (45 min) shows liver S9 stability with t1/2 values of 842 min and >45 min in Phase I and phase II in human liver, respectively; and t1/2 values of 28.9 min and >45 min in Phase I and phase II in mouse liver, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2816165-16-7
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Molecular Weight 455.49
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Formula C21H21N5O5S
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SMILES
O=S(C1=CC=C2C=CC=CC2=C1)(NC[C@H]3O[C@@H](C4=CC=C5C(N)=NC=NN54)[C@H](O)[C@@H]3O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2 nsp14-IN-2 Related Classifications
HY-150681 Related Classifications
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