SCC

By Targets:	Adenylate Cyclase (1) Antibiotic (1) Biochemical Assay Reagents (1) c-Met/HGFR (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) HSP (1) Phosphodiesterase (PDE) (1) Ras (1)
By Research Areas:	Cancer (4) Endocrinology (1) Infection (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116000

Glumetinib 1 Publications Verification Gumarontinib; SCC244	c-Met/HGFR	Cancer
Glumetinib (SCC244) is a highly selective, orally bioavailable, ATP-competitive c-Met inhibitor with an IC₅₀ of 0.42 nM. Glumetinib has greater than 2400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, TyrO3. Antitumor activity .

HY-111424

BDP9066	Ras	Cancer
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC₅₀ of 64 nM for MRCKβ in SCC12 cells, K_i values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

HY-125049

Kijanimicin

Sch 25663
Endogenous Metabolite Antibiotic Infection

Kijanimicin (Sch 25663) is an antibiotic produced by Actinomadura kijaniata SCC 1256 .

Kijanimicin Sch 25663	Endogenous Metabolite Antibiotic	Infection
Kijanimicin (Sch 25663) is an antibiotic produced by Actinomadura kijaniata SCC 1256 .

HY-101595

RPH-2823	Others	Others
RPH-2823, a basic triamterene derivative, induces a dose-dependent decrease in short-circuit current (SCC) and increase in transepithelial electrical resistance .

HY-103192

MDL12330A RMI12330A	Adenylate Cyclase Phosphodiesterase (PDE)	Others
MDL12330A (RMI12330A) is an adenyl cyclase inhibitor. MDL12330A inhibits the vasopressin action on the short-circuit current (SCC). MDL12330A is also an inhibitor of cAMP phosphodiesterase .

HY-122502

Pyrazofurin	DNA/RNA Synthesis	Cancer
Pyrazofurin, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5'-phosphate (UMP) synthase . Pyrazofurin is an active, sensitive orotate-phosphoribosyltransferase inhibitor with IC₅₀s between 0.06-0.37 µM in the three squamous cell carcinoma (SCC) cell lines Hep-2, HNSCC-14B and HNSCC-14C .

HY-114664

KNK423	HSP	Infection Cancer
KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research .

HY-A0234

Stepronin Prostenoglycine; TTPG; Tiase	Others	Endocrinology
Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl ^- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands .

HY-W127393

N-Nonanoyl-L-homoserine lactone	Biochemical Assay Reagents	Others
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.

Cat. No.	Product Name	Type

HY-W127393

N-Nonanoyl-L-homoserine lactone	Biochemical Assay Reagents
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.

N-Nonanoyl-L-homoserine lactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125049

Kijanimicin Sch 25663	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Fields Other Antibiotics	Endogenous Metabolite Antibiotic
Kijanimicin (Sch 25663) is an antibiotic produced by Actinomadura kijaniata SCC 1256 .

Cat. No.	Compare	Product Name	Species	Source

HY-P76682

	TNFAIP8 Protein, Human (His) Tumor necrosis factor alpha-induced protein 8; MDC-3.13; NDED; SCC-S2; TNF-induced protein GG2-1	Human	E. coli
	TNFAIP8 Protein functions as a negative regulator of apoptosis, inhibiting caspase-8 activity and suppressing TNF-mediated apoptosis without affecting procaspase-8 processing. This control prevents BID cleavage and subsequent caspase-3 activation, contributing to cellular survival mechanisms. TNFAIP8's role highlights its potential significance in apoptosis regulation and its implications for tumor development. TNFAIP8 Protein, Human (His) is the recombinant human-derived TNFAIP8 protein, expressed by E. coli, with N-His labeled tag. The total length of TNFAIP8 Protein, Human (His) is 198 a.a., with molecular weight of ~26 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81402

SA2 Antibody (YA1147)

SA 2; SA-2; SA2; SCC3 homolog 2; SCC3B; stag2; Stromal antigen 2
IHC-P Human
HY-P81855

TNFAIP8 Antibody (YA1600)

TNF alpha-induced protein 8; NDED; SCC-S2
WB, IP Human
HY-P83240

Rad21 Antibody (YA2985)

RAD21; HR21; KIAA0078; NXP1; Double-strand-break repair protein rad21 homolog; hHR21; Nuclear matrix protein 1; NXP-1; SCC1 homolog
WB, FC Human, Mouse, Rat

HY-P81223

CYP11A1 Antibody Cholesterol 20 22 desmolase； Cholesterol desmolase； Cholesterol monooxygenase (side chain cleaving)； Cholesterol side chain cleavage enzyme； Cholesterol side chain cleavage enzyme mitochondrial； Cholesterol side-chain cleavage enzyme； CP11A_HUMAN； CYP11A； CYPXIA1； Cytochrome P450 11A1； Cytochrome P450 11A1 mitochondrial； Cytochrome P450 family 11 subfamily A polypeptide 1； Cytochrome P450 subfamily XIA； Cytochrome P450(SCC)； Cytochrome P450C11A1； mitochondrial； P450SCC； Steroid 20 22 lyase	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Mouse, Rat(predicted: Dog, Pig, Cow, Horse, Rabbit, Sheep)
CYP11A1 Antibody is an unconjugated, approximately 53/57 kDa, rabbit-derived, anti-CYP11A1 polyclonal antibody. CYP11A1 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, and predicted: dog, pig, cow, horse, rabbit, sheep background without labeling.

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