SA2 Antibody (YA1147)
(Synonyms: SA 2; SA-2; SA2; SCC3 homolog 2; SCC3B; stag2; Stromal antigen 2)SA2 Antibody (YA1147) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SA2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.205.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
SA2 Antibody (YA1147) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SA2.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 141 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 141 kDa
Recombinant protein of human SA2
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.205.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SA2 component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis
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Subcellular Localization
Nucleus; Chromosome; Chromosome, centromere
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Isoforms & Post-Translational Modification
Q8N3U4 has 2 isomers: Q8N3U4-1: 141326 Da (predicted); Q8N3U4-2: 145751 Da (predicted).
Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity) -
Subunit
Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3
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SwissProt ID
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Synonyms
SA 2; SA-2; SA2; SCC3 homolog 2; SCC3B; stag2; Stromal antigen 2
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Research Field
Cell Biology
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