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Stepronin  (Synonyms: Prostenoglycine; TTPG; Tiase)

Cat. No.: HY-A0234 Purity: 99.93%
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Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands.

For research use only. We do not sell to patients.

Stepronin Chemical Structure

Stepronin Chemical Structure

CAS No. : 72324-18-6

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Based on 1 publication(s) in Google Scholar

Stepronin Related Antibodies

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Description

Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands[1].

In Vitro

Stepronin (0.1-100 µM; 20 min) induces significant reductions in ISOP(Isoproterenol)-evoked SCC (short circuit current) value in a dose-dependent manner in canine tracheal epithelium[1].
Stepronin (10-100 µM; 20 min) significantly inhibits the basal secretion and ISOP-evoked PD (potential difference) value in a dose-dependent manner in canine tracheal epithelium[1].
Stepronin (100 µM; 20 min) significantly inhibits ISOP-induced [3H]-glycoconjugate secretion in submucosal glands[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Stepronin Related Antibodies

Cell Viability Assay[1]

Cell Line: Canine tracheal epithelium (from adult and 10 to 25 kg-weight mongrel dogs of both sexes)
Concentration: 0.1-100 µM; 10-100 µM
Incubation Time: 20 min (pre-treat)
Result: Significantly inhibited ISOP-induced SCC and PD values, as well as basal secretion.

Cell Viability Assay[1]

Cell Line: Submucosal glands (from adult and 10 to 25 kg-weight mongrel dogs of both sexes)
Concentration: 100 µM
Incubation Time: 20 min (pre-treat)
Result: Significantly inhibited ISOP- induced [3H]-glycoconjugate secretion.
Molecular Weight

273.33

Formula

C10H11NO4S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CNC(C(SC(C1=CC=CS1)=O)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (914.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6586 mL 18.2929 mL 36.5858 mL
5 mM 0.7317 mL 3.6586 mL 7.3172 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6586 mL 18.2929 mL 36.5858 mL 91.4645 mL
5 mM 0.7317 mL 3.6586 mL 7.3172 mL 18.2929 mL
10 mM 0.3659 mL 1.8293 mL 3.6586 mL 9.1465 mL
15 mM 0.2439 mL 1.2195 mL 2.4391 mL 6.0976 mL
20 mM 0.1829 mL 0.9146 mL 1.8293 mL 4.5732 mL
25 mM 0.1463 mL 0.7317 mL 1.4634 mL 3.6586 mL
30 mM 0.1220 mL 0.6098 mL 1.2195 mL 3.0488 mL
40 mM 0.0915 mL 0.4573 mL 0.9146 mL 2.2866 mL
50 mM 0.0732 mL 0.3659 mL 0.7317 mL 1.8293 mL
60 mM 0.0610 mL 0.3049 mL 0.6098 mL 1.5244 mL
80 mM 0.0457 mL 0.2287 mL 0.4573 mL 1.1433 mL
100 mM 0.0366 mL 0.1829 mL 0.3659 mL 0.9146 mL
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Stepronin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stepronin72324-18-6Prostenoglycine TTPG TiaseOthersSCCshort circuit currentpotential differencecanine tracheal epitheliumsubmucosal glandsInhibitorinhibitorinhibit

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