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Results for "

TRPC1/5 heteromer

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

2

Peptides

2

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101507
    Zerencotrep
    10+ Cited Publications

    Pico145; HC-608

    		 TRP Channel Cancer
    Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 [1].
    Zerencotrep
  • HY-101202
    SNC80

    NIH 10815

    		 Opioid Receptor Neurological Disease
    SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment [1] .
    SNC80
  • HY-122351A
    Advantame

    		Taste Receptor Others
    Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K + channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits [1] .
    Advantame
  • HY-RS15104
    TRPC1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TRPC1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TRPC1 Human Pre-designed siRNA Set A
    TRPC1 Human Pre-designed siRNA Set A
  • HY-RS17997
    Trpc1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Trpc1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trpc1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Trpc1 Mouse Pre-designed siRNA Set A
    Trpc1 Mouse Pre-designed siRNA Set A
  • HY-RS24469
    Trpc1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Trpc1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trpc1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Trpc1 Rat Pre-designed siRNA Set A
    Trpc1 Rat Pre-designed siRNA Set A
  • HY-184164
    JD03-02

    		TRP Channel Neurological Disease
    JD03-02 is an orally active, blood-brain barrier-permeable TRPC1/5 heterodimer inhibitor with an IC50 of 0.2 nM. JD03-02 preferentially binds to a unique ligand-binding pocket at the interface of TRPC1-TRPC5, exerts almost no inhibitory effect on TRPC5 homotetramers, and thus avoids side effects such as obesity and hyperkinesia. JD03-02 induces anxiolytic and antidepressant effects in mouse models. JD03-02 can be used in studies related to depression and anxiety disorders [1].
    JD03-02
  • HY-P10405A
    TAT-D1 peptide acetate

    		Dopamine Receptor Neurological Disease
    TAT-D1 peptide acetate is a dopamine D1-D2 receptor heterodimer inhibitor. TAT-D1 peptide acetate disrupts the function of dopamine D1-D2 receptor heteromers, enhances subchronic amphetamine-induced locomotor activity, and exacerbates the expression of amphetamine-induced locomotor sensitization. TAT-D1 peptide acetate produces rapid anxiolytic and antidepressant-like effects in rat models of depression and anxiety, and inhibits c-fos expression in the nucleus accumbens of rats. TAT-D1 peptide acetate can be used in the research of psychostimulant addiction, depression and anxiety disorders [1] .
    TAT-D1 peptide acetate
  • HY-P10405
    TAT-D1 peptide

    		Dopamine Receptor Neurological Disease
    TAT-D1 peptide is a dopamine D1-D2 receptor heterodimer inhibitor. TAT-D1 peptide disrupts the function of dopamine D1-D2 receptor heteromers, enhances subchronic amphetamine-induced locomotor activity, and exacerbates the expression of amphetamine-induced locomotor sensitization. TAT-D1 peptide produces rapid anxiolytic and antidepressant-like effects in rat models of depression and anxiety, and inhibits c-fos expression in the nucleus accumbens of rats. TAT-D1 peptide can be used in the research of psychostimulant addiction, depression and anxiety disorders [1] .
    TAT-D1 peptide
  • HY-145308
    Heterobivalent ligand-1

    		Adenosine Receptor Dopamine Receptor Neurological Disease
    Heterobivalent ligand-1 (compound 26) is a heterobivalent ligand for the Adenosine A 2A-dopamine D 2 receptor heteromer (KDB1 A2AR=2.1 nM, KDB1 D2R= 0.13 nM) [1].
    Heterobivalent ligand-1
  • HY-138868
    17-Phenyl trinor prostaglandin E2 ethyl amide

    17-Phenyl trinor PGE2 ethyl amide

    		 Prostaglandin Receptor Metabolic Disease
    17-Phenyl trinor prostaglandin E2 ethyl amide (17-Phenyl trinor PGE2 ethyl amide) is a EP1 receptor agonist. 17-Phenyl trinor prostaglandin E2 ethyl amide aggravates renal dysfunction and glomerulosclerosis [1].
    17-Phenyl trinor prostaglandin E2 ethyl amide
  • HY-101507R
    Zerencotrep (Standard)

    Pico145 (Standard); HC-608 (Standard)

    		 TRP Channel Reference Standards Cancer
    Zerencotrep (Standard) is the analytical standard of Zerencotrep (HY-101507). This product is intended for research and analytical applications. Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 [1].
    Zerencotrep (Standard)
  • HY-177738
    6'Nicotinate Ac4ManNAz

    		Drug Derivative Neurological Disease Metabolic Disease
    6'Nicotinate Ac4ManNAz (Compound 2) is a brain-penetrant carbohydrate-neuroactive heteromer conjugating Ac4ManNAz (HY-W728531) and Nicotinic acid (HY-B0143). 6'Nicotinate Ac4ManNAz can be used for the development of glycosylation-regulating agents or diagnostic probes that cross the BBB [1].
    6'Nicotinate Ac4ManNAz
  • HY-122351
    Advantame free acid

    		Drug Derivative Taste Receptor Others
    Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K + channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits [1] .
    Advantame free acid
  • HY-122351AR
    Advantame (Standard)

    		Reference Standards Taste Receptor Others
    Advantame (Standard) is the analytical standard of Advantame. This product is intended for research and analytical applications. Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K + channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits [1] .
    Advantame (Standard)
  • HY-101202R
    SNC80 (Standard)

    NIH 10815 (Standard)

    		 Opioid Receptor Reference Standards Neurological Disease
    SNC80 (Standard) is the analytical standard of SNC80 (HY-101202). This product is intended for research and analytical applications. SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment [1] .
    SNC80 (Standard)

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