TrpC1 Antibody (YA9773)
(Synonyms: TRPC1, Transient Receptor Potential Cation Channel Subfamily C Member 1, HTRP-1, Short Transient Receptor Potential Channel 1, Transient Receptor Protein 1, TRP1, Transient Receptor Potential Cation Channel, Subfamily C, Member 1, Capacitative Calcium Channel Protein Trp1, Transient Receptor Potential Canonical 1, TrpC1, TRP-1)TrpC1 Antibody (YA9773) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to TrpC1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC, ICC/IF
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Reactivity :
Human, mouse, rat
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Formulation:
Supplied in PBS (pH 7.4) containing 50% glycerol, 0.05% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-5000 | 1:200-2000 | 1:100-1000 |
Product Details
TrpC1 Antibody (YA9773) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to TrpC1.
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Host Rabbit
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Species ReactivityHuman, mouse, rat
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Observed Molecular WeightObserved band size: 120 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 91 kDa
A synthesized peptide derived from human TRPC1
affinity purified.
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4) containing 50% glycerol, 0.05% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TrpC1 forms a receptor-activated non-selective calcium permeant cation channel. Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel. Also permeable to monovalent ions including sodium, lithium and cesium ions[1][2][3].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Seems to be ubiquitous. -
Isoforms & Post-Translational Modification
TrpC1 has 2 isoforms, P48995-1: amino acid length is 793, molecular weight is 91212 Da (predicted); P48995-2: amino acid length is 759, molecular weight is 87617 Da (predicted).Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells
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Subunit
Heterotetramer with TRPC4 and/or TRPC5.
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SwissProt ID
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Synonyms
TRPC1, Transient Receptor Potential Cation Channel Subfamily C Member 1, HTRP-1, Short Transient Receptor Potential Channel 1, Transient Receptor Protein 1, TRP1, Transient Receptor Potential Cation Channel, Subfamily C, Member 1, Capacitative Calcium Channel Protein Trp1, Transient Receptor Potential Canonical 1, TrpC1, TRP-1
Documentation
References
[1]. Xu SZ, et al. TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells. Circ Res. 2001 Jan 19;88(1):84-7. [Content Brief]
[2]. Ahmmed GU, et al. Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells. J Biol Chem. 2004 May 14;279(20):20941-9. [Content Brief]
[3]. Won J, et al. Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel. Nat Struct Mol Biol. 2025 Feb;32(2):326-338. [Content Brief]
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