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Results for "

Thiazolidinone

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Peptides

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108896
    Icatibant acetate
    10+ Cited Publications

    HOE 140 acetate

    		 Bradykinin Receptor Inflammation/Immunology
    Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively .
    Icatibant acetate
  • HY-153021
    NMT-IN-1

    		Parasite Infection
    NMT-IN-1 is a Trypanosoma brucei N-myristoyltransferase (TbNMT) inhibitor, with an IC50 of 31 μM against TbNMT and an IC50 of 66 μM against hNMT. As a thiazolidinone hit compound identified via virtual screening, NMT-IN-1 exerts enzymatic inhibitory effects by binding to the active site of TbNMT. NMT-IN-1 adopts a binding mode distinct from that of pyrazole sulfonamide inhibitors and can inhibit the myristoyl transfer reaction catalyzed by TbNMT. NMT-IN-1 is mainly used in the research of anti-parasitic lead compounds for human African trypanosomiasis (African sleeping sickness). It provides a structural basis for the subsequent optimization of TbNMT inhibitors with high activity, high selectivity and blood-brain barrier permeability .
    NMT-IN-1
  • HY-N14664
    Actithiazic acid

    		Antibiotic Bacterial Infection
    Actithiazic acid is a thiazolidinone antibiotic that targets biotin synthase. Actithiazic acid interferes with essential bacterial metabolism by inhibiting the final step of biotin synthesis (conversion of desthiobiotin to biotin, IC50 = 0.45 μM). Actithiazic acid can be used in studies related to mycobacterial infections .
    Actithiazic acid
  • HY-100284
    Thiazolidinone-Derivatives-1

    		Drug Derivative Inflammation/Immunology
    Thiazolidinone-Derivatives-1 is an antiulcer agent which inhibits the secretion of gastric acid.
    Thiazolidinone-Derivatives-1
  • HY-115995
    Antitumor agent-50

    		Drug Derivative Cancer
    Antitumor agent-50 (compound 1a), a thiazolidinone, is a potent antitumor agent. Antitumor agent-50 has the potential for osteosarcoma (OS) research .
    Antitumor agent-50
  • HY-104023
    ZK-Thiazolidinone

    		Polo-like Kinase (PLK) Cancer
    ZK-Thiazolidinone is an ATP-competitive Polo-like kinase 1 (Plk1) inhibitor with an IC50 of 19 nM. ZK-Thiazolidinone inhibits tumor cell proliferation, induces cell cycle arrest and typical mitotic defects. ZK-Thiazolidinone impairs the recruitment of γ-tubulin and Aurora A kinase to centrosomes, resulting in failure of bipolar spindle maintenance and sister chromatid arm cohesion.\nZK-Thiazolidinone is applicable for cancer research .
    ZK-Thiazolidinone
  • HY-115996
    Antitumor agent-51

    		Apoptosis Cancer
    Antitumor agent-51 possesses potent and selective inhibitory for osteosarcoma cell growth and migration with IC50 of 21.9 nM in MNNG/HOS cells. Antitumor agent-51 has a considerable bioavailability and a low toxicity .
    Antitumor agent-51
  • HY-161522
    α-Glucosidase-IN-63

    		Glycosidase Carbonic Anhydrase Endocrinology
    α-Glucosidase-IN-63 (Compound 4d) is an inhibitor of α-Glucosidase (IC50=0.44 μM). α-Glucosidase-IN-63 inhibits hCA II with an activity of Ki= 7.0 nM. α-Glucosidase-IN-63 is orally effective. .
    α-Glucosidase-IN-63
  • HY-149079
    Antiparasitic agent-15

    		Parasite Necroptosis Infection
    Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC50s of 0.9 μM and 0.64 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-15 has IC50s of 42.2 μM and 9.58 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes .
    Antiparasitic agent-15
  • HY-149080
    Antiparasitic agent-16

    		Parasite Necroptosis Infection
    Antiparasitic agent-16, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-16 has IC50s of 1.0 μM and 0.6 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-16 has IC50s of 150.2 μM and 16.75 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-16 induces parasite cell death through necrosis induction. Antiparasitic agent-16 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes .
    Antiparasitic agent-16
  • HY-181437
    Antiparasitic agent-40

    		Parasite Aminopeptidase Infection
    Antiparasitic agent-40 (compound 4.3) is a 4-thiazolidinone-based antileishmaniasis inhibitor. Antiparasitic agent-40 exhibits significant inhibitory activity against methionine aminopeptidase .
    Antiparasitic agent-40
  • HY-118903
    PIK-124

    		PI3K Cancer
    PIK-124 is a thiazolidinone-based PI3Kγ-biased PI3K inhibitor, with an IC50 of 3 nM against PI3Kγ. PIK-124 exhibits cross-reactivity with PI3Kα (IC50 = 23 nM), PI3Kδ (IC50 = 340 nM), PI3KC2α (IC50 = 140 nM) and PI3KC2β (IC50 = 370 nM). PIK-124 is applicable to breast cancer-related research .
    PIK-124

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