Antiparasitic agent-16
Antiparasitic agent-16, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-16 has IC50s of 1.0 μM and 0.6 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-16 has IC50s of 150.2 μM and 16.75 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-16 induces parasite cell death through necrosis induction. Antiparasitic agent-16 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes.
For research use only. We do not sell to patients.
- CAS No.: 3046451-89-9
- Formula: C18H18N4OS
- Molecular Weight:338.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Trypanosoma |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | CC50 |
47.4 μM
Compound: 15
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Cytotoxicity against mouse RAW264.7 cells incubated for 48 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells incubated for 48 hrs by MTT assay
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[PMID: 37062170] |
Antiparasitic agent-16 (compound 15) has a CC50 of 47.4 μM in RAW 264.7[1].
Antiparasitic agent-16 (1.0, 2.0 μM; 24 h) promotes morphological changes such as shortening, retraction and curvature of the parasite body in trypomastigotes forms of T. cruzi. Antiparasitic agent-16 dose-dependently induces significant alterations compatible with apoptosis in trypomastigotes[1].
Antiparasitic agent-16 (10 μg/mL; 24 h, 48 h, 72 h, and 96 h) causes a significant reduction in IL-10 production in supernatants of stimulated murine splenocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3046451-89-9
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Molecular Weight 338.43
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Formula C18H18N4OS
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SMILES
CC(C1S/C(N(C1=O)C2=CC=CC=C2)=N/N=C/C3=CC=CC=N3)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiparasitic agent-16 Related Classifications
HY-149080 Related Classifications
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