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Results for "

Tumor+hypoxia

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-105129
    Pimonidazole hydrochloride
    5+ Cited Publications

    		 Biochemical Assay Reagents Cancer
    Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
    Pimonidazole hydrochloride
  • HY-105129A
    Pimonidazole
    5+ Cited Publications

    		 Biochemical Assay Reagents Cancer
    Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
    Pimonidazole
  • HY-152293
    EVT801

    		VEGFR ERK Cancer
    EVT801 is an orally active and selective inhibitor of VEGFR-3 (IC50=11 nM), which has antitumor effects. EVT801 inhibits not only VEGF-C-induced human endothelial cell proliferation, but also tumor (lymphatic) angiogenesis in tumor mouse models. EVT801 can reduce tumor hypoxia, immunosuppressive cytokines (CCL4, CCL5) and myeloid derived suppressor cells (MDSC) production. EVT801 has synergistic effect with immune checkpoint therapy (ICT), which improves ICT response rate and has better inhibitory effect on cancer mouse models . EVT801 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    EVT801
  • HY-158189
    TPP-Ce6

    		Photosensitizer Reactive Oxygen Species (ROS) Apoptosis Neurological Disease Cancer
    TPP-Ce6 is a mitochondria-targeted photosensitizer formed by the ester bond conjugation of chlorophyll e6 (Ce6) with triphenylphosphine (TPP). Under light irradiation or ultrasound exposure, TPP-Ce6 generates reactive oxygen species, induces cell apoptosis, and triggers immunogenic cell death. TPP-Ce6 can serve as a component of carrier-free co-delivery systems, undergo enzyme-induced self-assembly within tumors, and modulate tumor hypoxia. TPP-Ce6 is applicable to research on breast cancer and glioblastoma .
    TPP-Ce6
  • HY-105129AS
    Pimonidazole-d10

    		Isotope-Labeled Compounds Cancer
    Pimonidazole-d10 is the deuterium labeled Pimonidazole. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
    Pimonidazole-d10
  • HY-105129R
    Pimonidazole hydrochloride (Standard)

    		Reference Standards Others Cancer
    Pimonidazole (hydrochloride) (Standard) is the analytical standard of Pimonidazole (hydrochloride). This product is intended for research and analytical applications. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
    Pimonidazole hydrochloride (Standard)
  • HY-105129AR
    Pimonidazole (Standard)

    		Reference Standards Others Cancer
    Pimonidazole (Standard) is the analytical standard of Pimonidazole. This product is intended for research and analytical applications. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
    Pimonidazole (Standard)
  • HY-163545
    Tc-Me2P

    		Drug Derivative Cancer
    Tc-Me2P is a 99MTC-labeled acrylamide (PnAO) derivative that contains two 4-methyl-2-nitroimidazole groups. The primary activity of Tc-Me2P is as an imaging agent for tumor hypoxia. By specifically binding to hypoxic regions in tumor tissue, it can be used for single photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging to detect hypoxia in tumors. Tc-Me2P can be used to study the targeting of different chemical structures in tumors and normal tissues .
    Tc-Me2P
  • HY-176724
    ZnPc-O3-JQ1

    		Epigenetic Reader Domain Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase Cancer
    ZnPc-O3-JQ1 is a light-triggered BRD4 degrader. Under illumination, ZnPc-O3-JQ1 generates reactive oxygen species (ROS) that degrades BRD4. The degradation of BRD4 results in downregulation of HIF-1α, thereby counteracting the photodynamic therapy (PDT) resistance induced by tumor hypoxia. ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 consists of three parts: BRD4 ligand (HY-78695); Linker (HY-W040165); Photosensitizer (HY-176725) .
    ZnPc-O3-JQ1
  • HY-116156
    SR-4554

    		Biochemical Assay Reagents Cancer
    SR-4554 is a probe for the measurement of tumor hypoxia. SR-4554 undergoes enzymatic single-electron reduction reactions within hypoxic cells. SR-4554 determines the 19F retention index for four commonly used mouse tumors (EMT6, SCCVII, KILT and RIF-I) through 19F MRS technique. SR-4554 can used to detect tumor Hypoxia noninvasively by 19F magnetic resonance spectroscopy ( 19F MRS) .
    SR-4554
  • HY-185401
    ATSM

    		MOFs Cancer
    ATSM is a ligand that forms complexes with Cu 2+, Ni 2+, Zn 2+, and Fe 2+, with the highest affinity for Cu 2+. ATSM forms Cu-ATSM with copper, which is used for PET imaging to detect tumor hypoxia. ATSM is commonly used in coordination chemistry and radiopharmaceutical research .
    ATSM
  • HY-183844
    C5F2-HCB

    		Cancer
    C5F2-HCB is a CYP-mediated inhibitor of the biosynthesis of arachidonic acid epoxygenase product (±) 14,15-EET (HY-150084), with an IC50 of 3.1 μM. C5F2-HCB inhibits EET-driven oxidative phosphorylation (OXPHOS) associated with tumor hypoxia, converting an immunologically "cold" tumor microenvironment into a "hot" one. C5F2-HCB reverses the immune-excluded tumor microenvironment in ER +HER2 − breast cancer allograft models. C5F2-HCB can be used in research related to ER +HER2 − breast cancer .
    C5F2-HCB

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