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  4. SR-4554

SR-4554 is a probe for the measurement of tumor hypoxia. SR-4554 undergoes enzymatic single-electron reduction reactions within hypoxic cells. SR-4554 determines the 19F retention index for four commonly used mouse tumors (EMT6, SCCVII, KILT and RIF-I) through 19F MRS technique. SR-4554 can used to detect tumor Hypoxia noninvasively by 19F magnetic resonance spectroscopy (19F MRS).

For research use only. We do not sell to patients.

SR-4554

SR-4554 Chemical Structure

CAS No. : 167648-73-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

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Description

SR-4554 is a probe for the measurement of tumor hypoxia. SR-4554 undergoes enzymatic single-electron reduction reactions within hypoxic cells. SR-4554 determines the 19F retention index for four commonly used mouse tumors (EMT6, SCCVII, KILT and RIF-I) through 19F MRS technique. SR-4554 can used to detect tumor Hypoxia noninvasively by 19F magnetic resonance spectroscopy (19F MRS)[1].

Parmacokinetics
Species Dose Route Tmax T1/2 Clearance (CL) Vd AUC0-∞
Mice[1] 180 mg/kg i.p. 45 min 51 min 29 mL/min/kg 1.8 L/kg 0.36 μM·h
Molecular Weight

282.18

Formula

C8H9F3N4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC(O)C(F)(F)F)CN1C=CN=C1[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (354.38 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5438 mL 17.7192 mL 35.4384 mL
5 mM 0.7088 mL 3.5438 mL 7.0877 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5438 mL 17.7192 mL 35.4384 mL 88.5959 mL
5 mM 0.7088 mL 3.5438 mL 7.0877 mL 17.7192 mL
10 mM 0.3544 mL 1.7719 mL 3.5438 mL 8.8596 mL
15 mM 0.2363 mL 1.1813 mL 2.3626 mL 5.9064 mL
20 mM 0.1772 mL 0.8860 mL 1.7719 mL 4.4298 mL
25 mM 0.1418 mL 0.7088 mL 1.4175 mL 3.5438 mL
30 mM 0.1181 mL 0.5906 mL 1.1813 mL 2.9532 mL
40 mM 0.0886 mL 0.4430 mL 0.8860 mL 2.2149 mL
50 mM 0.0709 mL 0.3544 mL 0.7088 mL 1.7719 mL
60 mM 0.0591 mL 0.2953 mL 0.5906 mL 1.4766 mL
80 mM 0.0443 mL 0.2215 mL 0.4430 mL 1.1074 mL
100 mM 0.0354 mL 0.1772 mL 0.3544 mL 0.8860 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR-4554167648-73-9SR4554SR 4554Biochemical Assay ReagentsTumor hypoxia detectionFluorinated 2-nitroimidazole probe19F magnetic resonance spectroscopy (19F MRS)Inhibitorinhibitorinhibit

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