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Pathways Recommended:	Stem Cell/Wnt Neuronal Signaling JAK/STAT Signaling

Results for "

Wnt/lrp6/β-catenin signaling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Wnt (11) β-catenin (10) Amyloid-β (1) Antibiotic (4) Apoptosis (5) Autophagy (4) Bacterial (4) c-Myc (1) Carboxypeptidase (1) Fluorescent Dye (1) HDAC (1) Mitophagy (2) Parasite (4) Porcupine (1) Reference Standards (2) Tau Protein (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (2) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (3)

Targets Recommended: β-catenin Wnt RGS Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17439

Salinomycin sodium salt Maximum Cited Publications 50 Publications Verification Salinomycin sodium; Sodium salinomycin	Wnt β-catenin Bacterial Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of *Wnt/β-catenin* signaling. Salinomycin sodium salt acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt shows selective activity against human cancer stem cells .

HY-15597

Salinomycin Maximum Cited Publications 50 Publications Verification Procoxacin	Bacterial Wnt β-catenin Mitophagy Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of *Wnt/β-catenin* signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells .

HY-122816

HLY78 10+ Cited Publications	Wnt β-catenin Apoptosis	Cardiovascular Disease Neurological Disease Cancer
HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the *Wnt/β-catenin* signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research .

HY-D0961

Gallocyanine chloride	Fluorescent Dye Wnt β-catenin	Neurological Disease Inflammation/Immunology Cancer
Gallocyanine chloride is a synthetic blue dyestuff that can be used as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies. Gallocyanine chloride inhibits *DKK1/LRP6* interaction (IC₅₀=6.38 μM), activates *Wnt* signaling pathway, and causes β-catenin accumulation. Gallocyanine chloride exhibits anti-metastasis, anti-inflammatory and anti-fibrosis activities. Gallocyanine chloride can be used as a fluorescent probe for detection of superoxide anion radicals .

HY-70005

CPA inhibitor 3 Publications Verification Carboxypeptidase inhibitor	Carboxypeptidase Wnt β-catenin	Inflammation/Immunology
CPA inhibitor (Compound 5) (Carboxypeptidase inhibitor) is an orally active competitive carboxypeptidase A (CPA) inhibitor with a K_i value of 0.32 μM. CPA inhibitor blocks the activity of carboxypeptidase A3 (CPA3). CPA activator activates the *Wnt/Lrp6/β-catenin* signaling pathway. CPA inhibitor reduces epithelial damage. CPA inhibitor is applicable to research related to inflammatory bowel disease, including ulcerative colitis and Crohn's disease .

HY-17439R

Salinomycin sodium salt (Standard) Salinomycin sodium (Standard); Sodium salinomycin (Standard)	Reference Standards Wnt β-catenin Bacterial Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin (sodium salt) (Standard) is the analytical standard of Salinomycin (sodium salt). This product is intended for research and analytical applications. Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem cells .

HY-176488

Y-99	Porcupine Wnt β-catenin c-Myc	Cancer
Y-99 is a PORCN inhibitor with an IC₅₀ of 155.4 nM against the *Wnt/β-catenin* signaling pathway. Y-99 inhibits the expression of *p-LRP6, β-catenin, and c-Myc* .

HY-15597R

Salinomycin (Standard) Procoxacin (Standard)	Reference Standards Bacterial Wnt β-catenin Mitophagy Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin (Standard) is the analytical standard of Salinomycin. This product is intended for research and analytical applications. Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells[1][2][3].

HY-181560

SLD1121	Wnt β-catenin	Metabolic Disease
SLD1121 is an agonist of the *Wnt/β-catenin* signaling pathway that enhances *Wnt* signaling by targeting *LRP6* (K_d: 4.52-7.49 nM). SLD1121 interacts with the intracellular domain of *LRP6, stabilizes LRP6, promotes its nuclear translocation, and facilitates its binding to β-catenin, TCF4* or LEF1 in the nucleus, thereby inducing the expression of *Wnt*-regulated genes and stem cell-related genes. SLD1121 induces the transition of hair follicles from telogen to anagen in the mouse hair growth cycle and promotes hair growth in mice. SLD1121 is applicable to hair loss-related research .

HY-E70390

C1s Enzyme masp-2, c1 esterase, c1-esterase	Wnt	Cardiovascular Disease Inflammation/Immunology
C1s Enzyme is a subunit of the complement C1 complex, which activates the complement as a serine protease. C1s Enzyme cleaves LRP5 and LRP6, and thus activates the *Wnt/β-Catenin* signaling pathway. C1s Enzyme promotes the macrophage M2 polarization and inhibits M1 polarization. C1s Enzyme enhances efferocytosis, exhibits anti-inflammatory activity .

HY-184177

W2A-28	HDAC Wnt β-catenin Tau Protein Amyloid-β	Neurological Disease
W2A-28 is a daul modulator of class I HDACs and *Wnt/β-catenin. W2A-28 inhibits HDAC1, 2 and 3 activities with IC₅₀ values of 512, 675, and 217 nM, respectively. W2A-28 shows selectivity over other HDACs and Sirtuin* family members. W2A-28 activates *Wnt/β-catenin* signaling via reduced *LRP6* degradation, enhances histone acetylation, suppresses tau phosphorylation, and reduces Aβ₄₀ and Aβ₄₂ levels. W2A-28 can be used for the research of Alzheimer's disease .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Wnt/lrp6/β-catenin signaling

Inhibitors & Agonists