2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. SLD1121

SLD1121 is an agonist of the Wnt/β-catenin signaling pathway that enhances Wnt signaling by targeting LRP6 (Kd: 4.52-7.49 nM). SLD1121 interacts with the intracellular domain of LRP6, stabilizes LRP6, promotes its nuclear translocation, and facilitates its binding to β-catenin, TCF4 or LEF1 in the nucleus, thereby inducing the expression of Wnt-regulated genes and stem cell-related genes. SLD1121 induces the transition of hair follicles from telogen to anagen in the mouse hair growth cycle and promotes hair growth in mice. SLD1121 is applicable to hair loss-related research.

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SLD1121

SLD1121 Chemical Structure

CAS No. : 2759011-75-9

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SLD1121 Related Antibodies

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Description

SLD1121 is an agonist of the Wnt/β-catenin signaling pathway that enhances Wnt signaling by targeting LRP6 (Kd: 4.52-7.49 nM). SLD1121 interacts with the intracellular domain of LRP6, stabilizes LRP6, promotes its nuclear translocation, and facilitates its binding to β-catenin, TCF4 or LEF1 in the nucleus, thereby inducing the expression of Wnt-regulated genes and stem cell-related genes. SLD1121 induces the transition of hair follicles from telogen to anagen in the mouse hair growth cycle and promotes hair growth in mice. SLD1121 is applicable to hair loss-related research[1].

In Vitro

SLD1121 (0-2 μM; 24 h) activates the LRP6-mediated Wnt/β-catenin signaling pathway in HEK293T cells, with an EC50 of approximately 0.21 μM[1].
SLD1121 (1-2 μM; 24 h) activates the Wnt/β-catenin signaling pathway in HaCaT cells[1].
SLD1121 (0.25-2 μM; 4-24 h) dose- and time-dependently increases the levels of total LRP6 protein, phosphorylated LRP6 protein, as well as ABC and β-catenin in HEK293T and HaCaT cells, without altering the mRNA expression level of LRP6[1].
SLD1121 (2 μM; 24 h) directly interacts with LRP6 in HEK293T cells and increases the thermal stability of both endogenous and exogenous LRP6[1].
SLD1121 (0-2 μM; 12-24 h) promotes the nuclear translocation of LRP6 and increases the nuclear β-catenin level in HaCaT cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SLD1121 Related Antibodies

Real Time qPCR[1]

Cell Line: HaCaT cells
Concentration: 1 and 2 μM
Incubation Time: 24 h
Result: Upregulated the mRNA expression of Wnt target genes Axin2, LEF1, Snail1, OCT4, Twist1, Sox2, and CD44.
In Vivo

SLD1121 (2%; topical; daily; 17 days) activates Wnt/β-catenin signaling in depilated C57BL/6J mice, induces hair follicle transition from telogen to anagen, and significantly enhances hair regrowth and regrown hair weight[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (7-week-old female, depilated to induce synchronized hair follicle telogen phase)[1]
Dosage: 2%
Administration: topical; daily; 17 days
Result: Induced gray skin (indicating early anagen transition) on day 9.
Showed significantly higher hair coat recovery rates compared to vehicle controls on days 11, 15, and 17.
Increased regrown hair weight significantly relative to vehicle controls on day 17.
Increased anagen-phase hair follicle numbers and dermal thickness compared to vehicle-treated mice (remained in telogen) via histological H&E staining.
Upregulated protein levels of phosphorylated LRP6, total LRP6, ABC, β-catenin, cytokeratin 15, and cytokeratin 17 significantly via western blotting.
Increased expression of LRP6, β-catenin, ABC, cytokeratin 15, cytokeratin 17, and proliferative marker Ki67 in skin tissues confirmed via immunohistochemical staining.
Increased expression of Sox2 and Snail in hair follicles shown via immunofluorescence staining.
Molecular Weight

415.45

Formula

C26H17N5O
CAS No.
SMILES

O=C(NC1=CC=CC=C1)C(C=C2)=CC=C2C3=NC4=C5C(N=CC=C5)=C6C(C=CC=N6)=C4N3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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SLD1121 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLD11212759011-75-9SLD 1121SLD-1121Wntβ-cateninBeta cateninLEF1HaCaT cellsWnt/β-catenin signalinghair folliclesLRP6HEK293T cellsC57BL/6J micealopeciaInhibitorinhibitorinhibit

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