2759011-75-9
Chemical Structure
SLD1121
- CAS No.: 2759011-75-9
- Formula:C26H17N5O
- Molecular Weight:415.45
InChIKey: XIOOPLIVMIHXQW-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC=C1)C(C=C2)=CC=C2C3=NC4=C5C(N=CC=C5)=C6C(C=CC=N6)=C4N3
Biological Activity: SLD1121 is an agonist of the Wnt/β-catenin signaling pathway that enhances Wnt signaling by targeting LRP6 (Kd: 4.52-7.49 nM). SLD1121 interacts with the intracellular domain of LRP6, stabilizes LRP6, promotes its nuclear translocation, and facilitates its binding to β-catenin, TCF4 or LEF1 in the nucleus, thereby inducing the expression of Wnt-regulated genes and stem cell-related genes. SLD1121 induces the transition of hair follicles from telogen to anagen in the mouse hair growth cycle and promotes hair growth in mice. SLD1121 is applicable to hair loss-related research[1].
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SLD1121 | SLD1121 is an agonist of the Wnt/β-catenin signaling pathway that enhances Wnt signaling by targeting LRP6 (Kd: 4.52-7.49 nM). SLD1121 interacts with the intracellular domain of LRP6, stabilizes LRP6, promotes its nuclear translocation, and facilitates its binding to β-catenin, TCF4 or LEF1 in the nucleus, thereby inducing the expression of Wnt-regulated genes and stem cell-related genes. SLD1121 induces the transition of hair follicles from telogen to anagen in the mouse hair growth cycle and promotes hair growth in mice. SLD1121 is applicable to hair loss-related research. | |||||||||||||||||||||
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Keywords
