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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

antibody-drug conjugate development

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (3) ADC Payload (1) Amino Acid Derivatives (1) Biochemical Assay Reagents (1) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (1) Glucocorticoid Receptor (1)
By Research Areas:	Cancer (4) Inflammation/Immunology (2) Metabolic Disease (1)
Click Chemistry:	Tetrazine (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Click Chemistry

Targets Recommended: Antibody-Drug Conjugates (ADCs) ADC Linker

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132180A

Seco-DUBA	ADC Payload DNA/RNA Synthesis	Inflammation/Immunology Cancer
Seco-DUBA hydrochloride is a DNA-targeting cytotoxic agent. Seco-DUBA hydrochloride binds to the minor groove of A-T-rich DNA regions, alkylates the adenine N3 residue, and undergoes spontaneous spirocyclization to generate active DUBA (HY-160969). Seco-DUBA hydrochloride exerts cytotoxic activity against human cancer cells. The reduced hydrophobicity of Seco-DUBA hydrochloride supports the development of antibody-drug conjugates .

HY-42709

Z-Val-Ala-OH Carbobenzoxy-L-valyl-L-alanine	Amino Acid Derivatives	Cancer
Z-Val-Ala-OH is a dipeptide derivative of valine and alanine. Z-Val-Ala-OH undergoes cleavage by cathepsin B and other lysosomal proteases to enable payload release following lysosomal internalization. Z-Val-Ala-OH can be used for the research of antibody-drug conjugate (ADC) development[1] .

HY-151727

Norbornene-NHS	ADC Linker	Others
Norbornene-NHS is a norbornene-functionalized antibody-drug conjugate linker (ADC Linker) bearing an NHS ester, which is applicable for highly efficient and specific antibody conjugation reactions in ADC research and development. Norbornene-NHS also acts as an azide-group-containing click chemistry reagent, serving as a dienophile for copper-free click reaction conjugation .

HY-156905

6-Azido-N-acetylgalactosamine-UDP	Biochemical Assay Reagents	Others
6-Azido-N-acetylgalactosamine-UDP (Compound 5) is a 6-azido-modified nucleotide sugar. It acts as an active sugar donor in lactose glycosylation catalyzed by beta-1,3-N-Acetylhexaminyltransferase (LgtA). Azido-modified nucleotide sugars are strategically used in copper-free click chemistry to modify the N-glycan core structure of IgG .

HY-44370

Boc-Gly-Gly-Gly-Gly-Gly	ADC Linker	Cancer
(tert-Butoxycarbonyl)glycyl-glycyl-glycyl-glycyl-glycine is an ADC linker with a Boc group on the N terminus, and it is used for the development of antibody-drug conjugates (ADCs). The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-130695

N-(Amino-PEG5)-N-bis(PEG4-acid)	ADC Linker	Cancer
N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG derivative containing an amino group with two terminal carboxylic acids. The amino group is reactive with carboxylic acids, activated NHS esters. The terminal carboxylic acids can react with primary amine groups in the presence of activators to form a stable amide bond. N-(Amino-PEG5)-N-bis(PEG4-acid) can be useful in the development of antibody drug conjugates (ADCs) .

HY-163672

Glucocorticoid receptor modulator 3	Glucocorticoid Receptor	Metabolic Disease Inflammation/Immunology
Glucocorticoid receptor modulator 3 (Payload 6) is a thioester-containing glucocorticoid receptor modulator (IC₅₀=0.6 nM). Glucocorticoid receptor modulator 3 is designed to inactivate unconjugated payloads rapidly through liver metabolism, thereby minimizing systemic exposure. Glucocorticoid receptor modulator 3 can be utilized in the development of antibody-drug conjugates (ADCs) targeting autoimmune diseases .

HY-183594

Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal	Drug-Linker Conjugates for ADC	Others
Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal is a linker-payload conjugate. Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal contains the linker D-2,4-DHB-NH2-AA(bPEG8)-Mal (HY-183595) and the cytotoxic agent Exatecan (HY-13631), a potent DNA topoisomerase I inhibitor. Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal can be utilized for the development of antibody-drug conjugates (ADCs) .

Cat. No.	Product Name

HY-L256

Azide Compound Library	0 compounds
In modern drug discovery and chemical biology research, the azide group (-N₃) is an important functional moiety that is widely used in click chemistry, biomolecular labeling, drug delivery systems, and prodrug design due to its unique reactivity and bioorthogonality. The MCE Azide Structural Compound Library contains 0 compounds featuring -N₃ functional groups. It is designed for the construction of click chemistry reaction systems and the subsequent development of functional molecules. This library enables the rapid assembly of targeting ligands, linkers, and functional molecular modules, thereby accelerating PROTAC assembly, optimization of antibody-drug conjugate (ADC) linkers, and the development of biological labeling probes. In addition, the high reaction selectivity and excellent biocompatibility of the azide group allow it to maintain stable reactivity even in complex biological environments, improving controllability and efficiency in drug design. It serves as an indispensable molecular tool in modern medicinal chemistry and chemical biology research.

Azide Compound Library

0 compounds

In modern drug discovery and chemical biology research, the azide group (-N₃) is an important functional moiety that is widely used in click chemistry, biomolecular labeling, drug delivery systems, and prodrug design due to its unique reactivity and bioorthogonality.

The MCE Azide Structural Compound Library contains 0 compounds featuring -N₃ functional groups. It is designed for the construction of click chemistry reaction systems and the subsequent development of functional molecules. This library enables the rapid assembly of targeting ligands, linkers, and functional molecular modules, thereby accelerating PROTAC assembly, optimization of antibody-drug conjugate (ADC) linkers, and the development of biological labeling probes. In addition, the high reaction selectivity and excellent biocompatibility of the azide group allow it to maintain stable reactivity even in complex biological environments, improving controllability and efficiency in drug design. It serves as an indispensable molecular tool in modern medicinal chemistry and chemical biology research.

Cat. No.	Product Name	Target	Research Area

HY-42709

Z-Val-Ala-OH Carbobenzoxy-L-valyl-L-alanine	Amino Acid Derivatives	Cancer
Z-Val-Ala-OH is a dipeptide derivative of valine and alanine. Z-Val-Ala-OH undergoes cleavage by cathepsin B and other lysosomal proteases to enable payload release following lysosomal internalization. Z-Val-Ala-OH can be used for the research of antibody-drug conjugate (ADC) development[1] .

Cat. No.	Product Name		Classification

HY-151727

Norbornene-NHS		Tetrazine
Norbornene-NHS is a norbornene-functionalized antibody-drug conjugate linker (ADC Linker) bearing an NHS ester, which is applicable for highly efficient and specific antibody conjugation reactions in ADC research and development. Norbornene-NHS also acts as an azide-group-containing click chemistry reagent, serving as a dienophile for copper-free click reaction conjugation .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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