country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-183594

Copy Link Print Information

Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal

Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal is a linker-payload conjugate. Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal contains the linker D-2,4-DHB-NH2-AA(bPEG8)-Mal (HY-183595) and the cytotoxic agent Exatecan (HY-13631), a potent DNA topoisomerase I inhibitor. Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal can be utilized for the development of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

CAS No.: 3037373-65-9
Formula: C₆₀H₈₁FN₈O₂₁
Molecular Weight:1269.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal Chemical Structure

CAS No.: 3037373-65-9

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal (compound 61) consists of the linker D-2,4-DHB-NH2-AA(bPEG8)-Mal (HY-183595) and the cytotoxic molecule Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC₅₀ of 2.2 μM (0.975 μg/mL)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3037373-65-9
Molecular Weight 1269.32
Formula C₆₀H₈₁FN₈O₂₁
SMILES

O=C(OC1)[C@@](CC)(O)C2=C1C(N3C(C4=NC5=C6C([C@@H](NC([C@H](O)CCOCNC([C@H](C)NC([C@H](C)NC([C@H](CNC(CCOCCOCCOCCOCCOCCOCCOCCOC)=O)N7C(C=CC7=O)=O)=O)=O)=O)=O)CCC6=C(C)C(F)=C5)=C4C3)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Quiroz RV, et al. Design of Novel Exatecan-Amide Linker-Payloads for the Development of Stable, Low-Aggregating, and Highly Efficacious Antibody-Drug Conjugates. J Med Chem. 2026;69(9):9928-9951. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal

100 mg Get Quote

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal

All Drug-Linker Conjugates for ADC Isoforms

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal Related Classifications

HY-183594 Related Classifications

Bioz

Keywords

Your Recently Viewed Products