Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal 

Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal is a linker-payload conjugate. Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal contains the linker D-2,4-DHB-NH2-AA(bPEG8)-Mal (HY-183595) and the cytotoxic agent Exatecan (HY-13631), a potent DNA topoisomerase I inhibitor. Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal can be utilized for the development of antibody-drug conjugates (ADCs)^[1].

Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal (compound 61) consists of the linker D-2,4-DHB-NH2-AA(bPEG8)-Mal (HY-183595) and the cytotoxic molecule Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC₅₀ of 2.2 μM (0.975 μg/mL)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1269.32

C₆₀H₈₁FN₈O₂₁

3037373-65-9

O=C(OC1)[C@@](CC)(O)C2=C1C(N3C(C4=NC5=C6C([C@@H](NC([C@H](O)CCOCNC([C@H](C)NC([C@H](C)NC([C@H](CNC(CCOCCOCCOCCOCCOCCOCCOCCOC)=O)N7C(C=CC7=O)=O)=O)=O)=O)=O)CCC6=C(C)C(F)=C5)=C4C3)=C2)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Quiroz RV, et al. Design of Novel Exatecan-Amide Linker-Payloads for the Development of Stable, Low-Aggregating, and Highly Efficacious Antibody-Drug Conjugates. J Med Chem. 2026;69(9):9928-9951.