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Referencia número: HY-183594

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Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal

Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal is a linker-payload conjugate. Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal contains the linker D-2,4-DHB-NH2-AA(bPEG8)-Mal (HY-183595) and the cytotoxic agent Exatecan (HY-13631), a potent DNA topoisomerase I inhibitor. Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal can be utilized for the development of antibody-drug conjugates (ADCs).

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No. CAS: 3037373-65-9
Fòrmula: C₆₀H₈₁FN₈O₂₁
Peso molecular:1269.32

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal Chemical Structure

No. CAS: 3037373-65-9

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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Drug-Linker Conjugates for ADC :

In Vitro

Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal (compound 61) consists of the linker D-2,4-DHB-NH2-AA(bPEG8)-Mal (HY-183595) and the cytotoxic molecule Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC₅₀ of 2.2 μM (0.975 μg/mL)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3037373-65-9
Peso molecular 1269.32
Fòrmula C₆₀H₈₁FN₈O₂₁
SMILES

O=C(OC1)[C@@](CC)(O)C2=C1C(N3C(C4=NC5=C6C([C@@H](NC([C@H](O)CCOCNC([C@H](C)NC([C@H](C)NC([C@H](CNC(CCOCCOCCOCCOCCOCCOCCOCCOC)=O)N7C(C=CC7=O)=O)=O)=O)=O)=O)CCC6=C(C)C(F)=C5)=C4C3)=C2)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Quiroz RV, et al. Design of Novel Exatecan-Amide Linker-Payloads for the Development of Stable, Low-Aggregating, and Highly Efficacious Antibody-Drug Conjugates. J Med Chem. 2026;69(9):9928-9951. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal

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Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal

Ver todos los productos específicos de isoformas Drug-Linker Conjugates for ADC

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal Related Classifications

HY-183594 Related Classifications

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