3037373-65-9
Chemical Structure
Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal
- CAS No.: 3037373-65-9
- Formula:C60H81FN8O21
- Molecular Weight:1269.32
InChIKey: GLLOWHKHGUXGNP-YADULJQGSA-N
SMILES: O=C(OC1)[C@@](CC)(O)C2=C1C(N3C(C4=NC5=C6C([C@@H](NC([C@H](O)CCOCNC([C@H](C)NC([C@H](C)NC([C@H](CNC(CCOCCOCCOCCOCCOCCOCCOCCOC)=O)N7C(C=CC7=O)=O)=O)=O)=O)=O)CCC6=C(C)C(F)=C5)=C4C3)=C2)=O
Biological Activity: Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal is a linker-payload conjugate. Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal contains the linker D-2,4-DHB-NH2-AA(bPEG8)-Mal (HY-183595) and the cytotoxic agent Exatecan (HY-13631), a potent DNA topoisomerase I inhibitor. Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal can be utilized for the development of antibody-drug conjugates (ADCs)[1].
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Exatecan-(D-2,4-DHB)-NH2-AA(bPEG8)-Mal | Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal is a linker-payload conjugate. Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal contains the linker D-2,4-DHB-NH2-AA(bPEG8)-Mal (HY-183595) and the cytotoxic agent Exatecan (HY-13631), a potent DNA topoisomerase I inhibitor. Exatecan-(D-2,4-DHB)-NH2-AA (bPEG8)-Mal can be utilized for the development of antibody-drug conjugates (ADCs). | |||||||||||||||||||||
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