6-Azido-N-acetylgalactosamine-UDP
Based on 1 Customer Validation
6-Azido-N-acetylgalactosamine-UDP (Compound 5) is a 6-azido-modified nucleotide sugar. It acts as an active sugar donor in lactose glycosylation catalyzed by beta-1,3-N-Acetylhexaminyltransferase (LgtA). Azido-modified nucleotide sugars are strategically used in copper-free click chemistry to modify the N-glycan core structure of IgG.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 1202854-87-2
- Formula: C17H26N6O16P2
- Molecular Weight:632.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
6-Azido-N-acetylgalactosamine-UDP serves as the active sugar donor in the lactose glycosylation process catalyzed by LgtA[1].
Azido-derived nucleotide sugars are strategically used in copper-free click chemistry to modify the N-glycan core structure of IgG[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1202854-87-2
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Appearance Solid
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Molecular Weight 632.37
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Formula C17H26N6O16P2
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Color White to off-white
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SMILES
O[C@H]([C@@H]1O)[C@H](N(C=CC2=O)C(N2)=O)O[C@@H]1CO[P](O[P](O[C@@H](O[C@@H]3CN=[N+]=[N-])[C@@H]([C@H]([C@H]3O)O)NC(C)=O)(O)=O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
H2O : 125 mg/mL (197.67 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Guan W, et al. Combining carbochips and mass spectrometry to study the donor specificity for the Neisseria meningitidis β1,3-N-acetylglucosaminyltransferase LgtA. Bioorg Med Chem Lett. 2011;21(17):5025-5028. [Content Brief]
[2]. Frohnmeyer H, et al. Process Development for the Enzymatic Gram-Scale Production of the Unnatural Nucleotide Sugar UDP-6-Azido-GalNAc. ChemSusChem. 2024;17(19):e202400311. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.5814 mL | 7.9068 mL | 15.8135 mL | 39.5338 mL |
| 5 mM | 0.3163 mL | 1.5814 mL | 3.1627 mL | 7.9068 mL | |
| 10 mM | 0.1581 mL | 0.7907 mL | 1.5814 mL | 3.9534 mL | |
| 15 mM | 0.1054 mL | 0.5271 mL | 1.0542 mL | 2.6356 mL | |
| 20 mM | 0.0791 mL | 0.3953 mL | 0.7907 mL | 1.9767 mL | |
| 25 mM | 0.0633 mL | 0.3163 mL | 0.6325 mL | 1.5814 mL | |
| 30 mM | 0.0527 mL | 0.2636 mL | 0.5271 mL | 1.3178 mL | |
| 40 mM | 0.0395 mL | 0.1977 mL | 0.3953 mL | 0.9883 mL | |
| 50 mM | 0.0316 mL | 0.1581 mL | 0.3163 mL | 0.7907 mL | |
| 60 mM | 0.0264 mL | 0.1318 mL | 0.2636 mL | 0.6589 mL | |
| 80 mM | 0.0198 mL | 0.0988 mL | 0.1977 mL | 0.4942 mL | |
| 100 mM | 0.0158 mL | 0.0791 mL | 0.1581 mL | 0.3953 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
6-Azido-N-acetylgalactosamine-UDP Related Classifications
HY-156905 Related Classifications
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Keywords
- 6-Azido-N-acetylgalactosamine-UDP
- 1202854-87-2
- Biochemical Assay Reagents
- β1,3-N-acetylglucosaminyltransferase LgtA
- antibody-drug conjugate development
- N-glycan core structure
- alkaline phosphatase
- IgGs
- copper-free click chemistry
- Neisseria meningitidis
- BlNahK/HsAGX1/ScPPase enzyme cascade
- glycan engineering
- Inhibitor
- inhibitor
- inhibit