6-Azido-N-acetylgalactosamine-UDP diammonium
6-Azido-N-acetylgalactosamine-UDP diammonium is a 6-azido-modified nucleotide sugar. 6-Azido-N-acetylgalactosamine-UDP diammonium acts as an active sugar donor in lactose glycosylation catalyzed by beta-1,3-N-Acetylhexaminyltransferase (LgtA). Azido-modified nucleotide sugars are strategically used in copper-free click chemistry to modify the N-glycan core structure of IgG.
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- CAS No.: 1202807-45-1
- Formula: C17H32N8O16P2
- Molecular Weight:666.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
6-Azido-N-acetylgalactosamine-UDP (Compound 5) diammonium serves as the active sugar donor in the lactose glycosylation process catalyzed by LgtA[1].
Azido-derived nucleotide sugars are strategically used in copper-free click chemistry to modify the N-glycan core structure of IgG[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1202807-45-1
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Molecular Weight 666.43
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Formula C17H32N8O16P2
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SMILES
O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@H]3O[C@H](CN=[N+]=[N-])[C@H](O)[C@H](O)[C@H]3NC(C)=O)(O)=O)(O)=O)O2)NC1=O.N.N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Guan W, et al. Combining carbochips and mass spectrometry to study the donor specificity for the Neisseria meningitidis β1,3-N-acetylglucosaminyltransferase LgtA. Bioorg Med Chem Lett. 2011;21(17):5025-5028. [Content Brief]
[2]. Frohnmeyer H, et al. Process Development for the Enzymatic Gram-Scale Production of the Unnatural Nucleotide Sugar UDP-6-Azido-GalNAc. ChemSusChem. 2024;17(19):e202400311. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6-Azido-N-acetylgalactosamine-UDP diammonium Related Classifications
HY-156905A Related Classifications
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Keywords
- 6-Azido-N-acetylgalactosamine-UDP diammonium
- 1202807-45-1
- Biochemical Assay Reagents
- β1,3-N-acetylglucosaminyltransferase LgtA
- antibody-drug conjugate development
- N-glycan core structure
- alkaline phosphatase
- IgGs
- copper-free click chemistry
- Neisseria meningitidis
- BlNahK/HsAGX1/ScPPase enzyme cascade
- glycan engineering
- Inhibitor
- inhibitor
- inhibit