1202807-45-1
Chemical Structure
6-Azido-N-acetylgalactosamine-UDP diammonium
- CAS No.: 1202807-45-1
- Formula:C17H32N8O16P2
- Molecular Weight:666.43
InChIKey: PRVBPOQWBWAHJN-AMMUOFBGSA-N
SMILES: O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@H]3O[C@H](CN=[N+]=[N-])[C@H](O)[C@H](O)[C@H]3NC(C)=O)(O)=O)(O)=O)O2)NC1=O.N.N
Biological Activity: 6-Azido-N-acetylgalactosamine-UDP diammonium is a 6-azido-modified nucleotide sugar. 6-Azido-N-acetylgalactosamine-UDP diammonium acts as an active sugar donor in lactose glycosylation catalyzed by beta-1,3-N-Acetylhexaminyltransferase (LgtA). Azido-modified nucleotide sugars are strategically used in copper-free click chemistry to modify the N-glycan core structure of IgG[1][2].
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6-Azido-N-acetylgalactosamine-UDP diammonium | 6-Azido-N-acetylgalactosamine-UDP diammonium is a 6-azido-modified nucleotide sugar. 6-Azido-N-acetylgalactosamine-UDP diammonium acts as an active sugar donor in lactose glycosylation catalyzed by beta-1,3-N-Acetylhexaminyltransferase (LgtA). Azido-modified nucleotide sugars are strategically used in copper-free click chemistry to modify the N-glycan core structure of IgG. | |||||||||||||||||||||
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- [1]. Guan W, et al. Combining carbochips and mass spectrometry to study the donor specificity for the Neisseria meningitidis β1,3-N-acetylglucosaminyltransferase LgtA. Bioorg Med Chem Lett. 2011;21(17):5025-5028. [Content Brief]
- [2]. Frohnmeyer H, et al. Process Development for the Enzymatic Gram-Scale Production of the Unnatural Nucleotide Sugar UDP-6-Azido-GalNAc. ChemSusChem. 2024;17(19):e202400311. [Content Brief]
