1202854-87-2
1202854-87-2
Chemical Structure
6-Azido-N-acetylgalactosamine-UDP
- CAS No.: 1202854-87-2
- Formula:C17H26N6O16P2
- Molecular Weight:632.37
InChIKey: SVLKKCJMKWWPQY-NESSUJCYSA-N
SMILES: O[C@H]([C@@H]1O)[C@H](N(C=CC2=O)C(N2)=O)O[C@@H]1CO[P](O[P](O[C@@H](O[C@@H]3CN=[N+]=[N-])[C@@H]([C@H]([C@H]3O)O)NC(C)=O)(O)=O)(O)=O
Biological Activity: 6-Azido-N-acetylgalactosamine-UDP (Compound 5) is a 6-azido-modified nucleotide sugar. It acts as an active sugar donor in lactose glycosylation catalyzed by beta-1,3-N-Acetylhexaminyltransferase (LgtA). Azido-modified nucleotide sugars are strategically used in copper-free click chemistry to modify the N-glycan core structure of IgG[1][2].
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6-Azido-N-acetylgalactosamine-UDP | 99.84% | 6-Azido-N-acetylgalactosamine-UDP (Compound 5) is a 6-azido-modified nucleotide sugar. It acts as an active sugar donor in lactose glycosylation catalyzed by beta-1,3-N-Acetylhexaminyltransferase (LgtA). Azido-modified nucleotide sugars are strategically used in copper-free click chemistry to modify the N-glycan core structure of IgG. | ||||||||||||||||||||
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References
- [1]. Guan W, et al. Combining carbochips and mass spectrometry to study the donor specificity for the Neisseria meningitidis β1,3-N-acetylglucosaminyltransferase LgtA. Bioorg Med Chem Lett. 2011;21(17):5025-5028. [Content Brief]
- [2]. Frohnmeyer H, et al. Process Development for the Enzymatic Gram-Scale Production of the Unnatural Nucleotide Sugar UDP-6-Azido-GalNAc. ChemSusChem. 2024;17(19):e202400311. [Content Brief]
