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carnitine palmitoyl-transferase I

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By Targets:	Carnitine Palmitoyltransferase (CPT) (5) Acyltransferase (2) Caspase (1) Endogenous Metabolite (3) Environmental Pollutants (1) Fungal (2) Mitochondrial Metabolism (4) Reactive Oxygen Species (ROS) (1) Reference Standards (2)
By Research Areas:	Infection (2) Inflammation/Immunology (2) Metabolic Disease (8) Neurological Disease (1)
Oligonucleotides:	Cationic Lipids (2)

10

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2

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3

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2

Oligonucleotides

Targets Recommended: Carnitine Palmitoyltransferase (CPT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Dodecanoylcarnitine 1 Publications Verification (-)-Lauroylcarnitine	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Dodecanoylcarnitine ((-)-Lauroylcarnitine) is a medium long-chain acylcarnitine, an intermediate product in key energy metabolic pathways of fatty acid β-oxidation and amino acids catabolism. The abnormal decrease in the Dodecanoylcarnitine levels indicats that mitochondrial fuel metabolism, including fatty acid oxidation is significantly disturbed. Changes in plasma concentrations of Dodecanoylcarnitine are not only associated with type II diabetes, but also with pre-diabetes status. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma. Combined model of Decanoylcarnitine (HY-113069), Dodecanoylcarnitine, PC (16:0/0:0), and Asp Arg Pro can be used as a potential biomarker for the diagnosis of Yin-deficiency-heat syndrome .

Thifluzamide	Environmental Pollutants Fungal Mitochondrial Metabolism	Infection
Thifluzamide is a fungicide that inhibits fungal respiration by blocking the ubiquinone-binding site in mitochondrial complex II. Thifluzamide exhibits significant activity against Basidiomycota pathogens (such as Rhizoctonia cerealis, Ustilago and Puccinia genera) and is commonly used in studies on wheat sharp eyespot. Thifluzamide displays a dual mechanism in regulating lipid metabolism: it reduces fatty acid synthase activity to inhibit endogenous fatty acid synthesis, and increases carnitine palmitoyltransferase-I activity to accelerate fatty acid β-oxidation, thereby reducing total cholesterol and triglyceride levels in the liver. Thifluzamide also induces hepatotoxicity in zebrafish models and carries a risk of developmental toxicity. Thifluzamide inhibition of Rhizoctonia cerealis may result in low to moderate levels of drug resistance, leading to the generation of stable drug-resistant mutants .

Perfluorododecanoic acid PFDoA	Reactive Oxygen Species (ROS) Caspase Mitochondrial Metabolism	Neurological Disease Metabolic Disease
Perfluorododecanoic acid (PFDoA) is an orally active, blood-brain barrier-permeable perfluorinated compound. Perfluorododecanoic acid increases Caspase 3 activity, disrupts mitochondrial membrane potential, and elevates ROS levels. Perfluorododecanoic acid induces cognitive deficits. Perfluorododecanoic acid exhibits hepatotoxicity .

McN3716 1 Publications Verification Methyl palmoxirate; NSC359682	Carnitine Palmitoyltransferase (CPT) Mitochondrial Metabolism	Metabolic Disease
McN3716 is a carnitine palmitoyltransferase I (CPT-1) inhibitor.

Docosahexaenoyl-L-carnitine chloride	Carnitine Palmitoyltransferase (CPT) Endogenous Metabolite	Metabolic Disease
Docosahexaenoyl-L-carnitine chloride is a long-chain acylcarnitine composed of Docosahexaenoic acid (HY-B2167) and L-carnitine (HY-B0399). Docosahexaenoyl-L-carnitine chloride is transported into mitochondria for β -oxidation and decomposition under the action of carnitine palmitoyltransferase I (CPT I) and others. Docosahexaenoyl-L-carnitine chloride is promising for research of diseases related to fatty acid metabolism .

4-Hydroxyphenylglyoxylate 4-Hydroxyphenylglyoxylic acid; 4-HPGA	Acyltransferase Carnitine Palmitoyltransferase (CPT)	Metabolic Disease
4-Hydroxyphenylglyoxylate (4-Hydroxyphenylglyoxylic acid) is an inhibitor of carnitine palmitoyltransferase I (CPT I). 4-Hydroxyphenylglyoxylate can be used to study sensitivity changes in CPT I of liver mitochondria and fatty acid oxidation by isolated hepatocytes. 4-Hydroxyphenylglyoxylate can inhibits fatty acid oxidation .

Thifluzamide (Standard)	Reference Standards Fungal Mitochondrial Metabolism	Infection
Thifluzamide (Standard) is the analytical standard of Thifluzamide. This product is intended for research and analytical applications. Thifluzamide is a fungicide that inhibits fungal respiration by blocking the ubiquinone-binding site in mitochondrial complex II. Thifluzamide exhibits significant activity against Basidiomycota pathogens (such as Rhizoctonia cerealis, Ustilago and Puccinia genera) and is commonly used in studies on wheat sharp eyespot. Thifluzamide displays a dual mechanism in regulating lipid metabolism: it reduces fatty acid synthase activity to inhibit endogenous fatty acid synthesis, and increases carnitine palmitoyltransferase-I activity to accelerate fatty acid β-oxidation, thereby reducing total cholesterol and triglyceride levels in the liver. Thifluzamide also induces hepatotoxicity in zebrafish models and carries a risk of developmental toxicity. Thifluzamide inhibition of Rhizoctonia cerealis may result in low to moderate levels of drug resistance, leading to the generation of stable drug-resistant mutants .

Dodecanoylcarnitine (Standard) (-)-Lauroylcarnitine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Dodecanoylcarnitine (Standard) is the analytical standard of Dodecanoylcarnitine (HY-113166). This product is intended for research and analytical applications. Dodecanoylcarnitine ((-)-Lauroylcarnitine) is a medium long-chain acylcarnitine, an intermediate product in key energy metabolic pathways of fatty acid β-oxidation and amino acids catabolism. The abnormal decrease in the Dodecanoylcarnitine levels indicats that mitochondrial fuel metabolism, including fatty acid oxidation is significantly disturbed. Changes in plasma concentrations of Dodecanoylcarnitine are not only associated with type II diabetes, but also with pre-diabetes status. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma. Combined model of Decanoylcarnitine (HY-113069), Dodecanoylcarnitine, PC (16:0/0:0), and Asp Arg Pro can be used as a potential biomarker for the diagnosis of Yin-deficiency-heat syndrome .

Hemiacetylcarnitinium chloride	Carnitine Palmitoyltransferase (CPT) Others	Metabolic Disease
Hemiacetylcarnitinium chloride is a inhibitor of fatty acid metabolism, specifically targeting carnitine palmitoyltransferase I (CPT I). Hemiacetylcarnitinium chloride disrupts the conversion of fatty acyl-CoA to fatty acyl carnitine, thereby blocking the subsequent oxidation of long-chain fatty acids and reducing the production of ATP required for energy-dependent cellular processes. Hemiacetylcarnitinium chloride can be used for the study of fatty acid metabolism .

Teglicar chloride ST1326 chloride	Carnitine Palmitoyltransferase (CPT) Acyltransferase	Metabolic Disease
Teglicar chloride (ST1326 chloride) is an orally active, reversible, mixed-type, selective inhibitor of hepatic carnitine palmitoyltransferase I (L-CPT I), with an IC₅₀ of 1.1 μM against rat L-CPT I. Teglicar chloride reduces serum glucose levels. Teglicar chloride exhibits antiketotic activity in normal fasted rats. Teglicar chloride can be used in research related to type 2 diabetes and ketoacidosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

Dodecanoylcarnitine 1 Publications Verification (-)-Lauroylcarnitine	Structural Classification Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Dodecanoylcarnitine ((-)-Lauroylcarnitine) is a medium long-chain acylcarnitine, an intermediate product in key energy metabolic pathways of fatty acid β-oxidation and amino acids catabolism. The abnormal decrease in the Dodecanoylcarnitine levels indicats that mitochondrial fuel metabolism, including fatty acid oxidation is significantly disturbed. Changes in plasma concentrations of Dodecanoylcarnitine are not only associated with type II diabetes, but also with pre-diabetes status. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma. Combined model of Decanoylcarnitine (HY-113069), Dodecanoylcarnitine, PC (16:0/0:0), and Asp Arg Pro can be used as a potential biomarker for the diagnosis of Yin-deficiency-heat syndrome .

Dodecanoylcarnitine (Standard) (-)-Lauroylcarnitine (Standard)	Structural Classification Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Dodecanoylcarnitine (Standard) is the analytical standard of Dodecanoylcarnitine (HY-113166). This product is intended for research and analytical applications. Dodecanoylcarnitine ((-)-Lauroylcarnitine) is a medium long-chain acylcarnitine, an intermediate product in key energy metabolic pathways of fatty acid β-oxidation and amino acids catabolism. The abnormal decrease in the Dodecanoylcarnitine levels indicats that mitochondrial fuel metabolism, including fatty acid oxidation is significantly disturbed. Changes in plasma concentrations of Dodecanoylcarnitine are not only associated with type II diabetes, but also with pre-diabetes status. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma. Combined model of Decanoylcarnitine (HY-113069), Dodecanoylcarnitine, PC (16:0/0:0), and Asp Arg Pro can be used as a potential biomarker for the diagnosis of Yin-deficiency-heat syndrome .

Host:	Rabbit (3)
Reactivity:	Human (2) Rat (1) Mouse (3)
Application:	IHC-P (2) ICC/IF (1) IP (1) IHC-F (1) WB (2)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Polyclonal (1) Monoclonal (2) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

	CPT1A Antibody (YA6515) carnitine O palmitoyltransferase 1 liver isoform antibody; carnitine O palmitoyltransferase I antibody; carnitine O palmitoyltransferase I liver isoform antibody; carnitine O-palmitoyltransferase 1 antibody; carnitine O-palmitoyltransferase I antibody; carnitine palmitoyltransferase 1A (liver) antibody; carnitine palmitoyltransferase 1A antibody; carnitine palmitoyltransferase I antibody; carnitine palmitoyltransferase I liver antibody; CPT 1 antibody; carnitine O palmitoyltransferase 1 liver isoform antibody; carnitine O palmitoyltransferase I antibody; carnitine O palmitoyltransferase I liver isoform antibody; carnitine O-palmitoyltransferase 1 antibody; carnitine O-palmitoyltransferase I antibody; carnitine palmitoyltransferase 1A (liver) antibody; carnitine palmitoyltransferase 1A antibody; carnitine palmitoyltransferase I antibody; carnitine palmitoyltransferase I liver antibody; CPT 1 antibody; CPT I antibody; CPT1 antibody; CPT1 L antibody; CPT1-L antibody; Cpt1a antibody; CPT1A_HUMAN antibody; CPTI antibody; CPTI-L antibody; L CPT1 antibody; liver isoform antibody;	WB	Mouse, Rat
	CPT1A Antibody (YA6515) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CPT1A.

	CPT1A Antibody CPT 1; CPT1A; CPTI-L; CPT1-L; carnitine palmitoyl transferase 1; carnitine O-palmitoyltransferase 1, liver isoform; CPT I; carnitine palmitoyltransferase 1A; carnitine O-palmitoyltransferase 1, liver isoform isoform 1; CPT1A_HUMAN.	IHC-P, IHC-F, ICC/IF	Human, Mouse
	CPT1A Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CPT1A.

	CPT1A Antibody (YA5862) carnitine O-palmitoyltransferase 1, liver isoform; CPT1-L; carnitine O-palmitoyltransferase I, liver isoform; CPT I; CPTI-L; carnitine palmitoyltransferase 1A;	WB, IHC-P, IP	Human, Mouse
	CPT1A Antibody (YA5862) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CPT1A.

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Cat. No.	Product Name		Classification

Dodecanoylcarnitine 1 Publications Verification (-)-Lauroylcarnitine		Cationic Lipids
Dodecanoylcarnitine ((-)-Lauroylcarnitine) is a medium long-chain acylcarnitine, an intermediate product in key energy metabolic pathways of fatty acid β-oxidation and amino acids catabolism. The abnormal decrease in the Dodecanoylcarnitine levels indicats that mitochondrial fuel metabolism, including fatty acid oxidation is significantly disturbed. Changes in plasma concentrations of Dodecanoylcarnitine are not only associated with type II diabetes, but also with pre-diabetes status. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma. Combined model of Decanoylcarnitine (HY-113069), Dodecanoylcarnitine, PC (16:0/0:0), and Asp Arg Pro can be used as a potential biomarker for the diagnosis of Yin-deficiency-heat syndrome .

Docosahexaenoyl-L-carnitine chloride		Cationic Lipids
Docosahexaenoyl-L-carnitine chloride is a long-chain acylcarnitine composed of Docosahexaenoic acid (HY-B2167) and L-carnitine (HY-B0399). Docosahexaenoyl-L-carnitine chloride is transported into mitochondria for β -oxidation and decomposition under the action of carnitine palmitoyltransferase I (CPT I) and others. Docosahexaenoyl-L-carnitine chloride is promising for research of diseases related to fatty acid metabolism .

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