CPT1A Antibody (YA6515)
(Synonyms: Carnitine O palmitoyltransferase 1 liver isoform antibody; Carnitine O palmitoyltransferase I antibody; Carnitine O palmitoyltransferase I liver isoform antibody; Carnitine O-palmitoyltransferase 1 antibody; Carnitine O-palmitoyltransferase I antibody; Carnitine palmitoyltransferase 1A (liver) antibody; Carnitine palmitoyltransferase 1A antibody; Carnitine palmitoyltransferase I antibody; Carnitine palmitoyltransferase I liver antibody; CPT 1 antibody; Carnitine O palmitoyltransferase 1 liver isoform antibody; Carnitine O palmitoyltransferase I antibody; Carnitine O palmitoyltransferase I liver isoform antibody; Carnitine O-palmitoyltransferase 1 antibody; Carnitine O-palmitoyltransferase I antibody; Carnitine palmitoyltransferase 1A (liver) antibody; Carnitine palmitoyltransferase 1A antibody; Carnitine palmitoyltransferase I antibody; Carnitine palmitoyltransferase I liver antibody; CPT 1 antibody; CPT I antibody; CPT1 antibody; CPT1 L antibody; CPT1-L antibody; Cpt1a antibody; CPT1A_HUMAN antibody; CPTI antibody; CPTI-L antibody; L CPT1 antibody; liver isoform antibody; )CPT1A Antibody (YA6515) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CPT1A.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:2000 |
Product Details
CPT1A Antibody (YA6515) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CPT1A.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityMouse, Rat
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Observed Molecular WeightObserved band size: 88 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 88 kDa
Recombinant protein within human CPT1A aa 201-773 / 773.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CPT1A catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity. Plays an important role in hepatic triglyceride metabolism. Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression. Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation. Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways[1][2][3][4][5][6].
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Subcellular Localization
Mitochondrion outer membrane
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Expression
Tissue_Specificity: Strong expression in kidney and heart, and lower in liver and skeletal muscle
Induction: Up-regulated by fatty acids -
Isoforms & Post-Translational Modification
P50416 has two isomers: P50416-1: 88368 Da (predicted); P50416-2: 86239 Da (predicted).
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Subunit
Homohexamer and homotrimer (By similarity)
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SwissProt ID
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Synonyms
Carnitine O palmitoyltransferase 1 liver isoform antibody; Carnitine O palmitoyltransferase I antibody; Carnitine O palmitoyltransferase I liver isoform antibody; Carnitine O-palmitoyltransferase 1 antibody; Carnitine O-palmitoyltransferase I antibody; Carnitine palmitoyltransferase 1A (liver) antibody; Carnitine palmitoyltransferase 1A antibody; Carnitine palmitoyltransferase I antibody; Carnitine palmitoyltransferase I liver antibody; CPT 1 antibody; Carnitine O palmitoyltransferase 1 liver isoform antibody; Carnitine O palmitoyltransferase I antibody; Carnitine O palmitoyltransferase I liver isoform antibody; Carnitine O-palmitoyltransferase 1 antibody; Carnitine O-palmitoyltransferase I antibody; Carnitine palmitoyltransferase 1A (liver) antibody; Carnitine palmitoyltransferase 1A antibody; Carnitine palmitoyltransferase I antibody; Carnitine palmitoyltransferase I liver antibody; CPT 1 antibody; CPT I antibody; CPT1 antibody; CPT1 L antibody; CPT1-L antibody; Cpt1a antibody; CPT1A_HUMAN antibody; CPTI antibody; CPTI-L antibody; L CPT1 antibody; liver isoform antibody;
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