CPT1A Antibody (YA6515)

Cat. No.: HY-P86822: Data Sheet User Guide for Antibodies
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CPT1A Antibody (YA6515) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CPT1A.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CPT1A Antibody (YA6515) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CPT1A.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 88 kDa;

Observed band size: 88 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Mouse, Rat

SwissProt ID

P50416

Gene ID

1374 [NCBI]

Immunogen

Recombinant protein within human CPT1A aa 201-773 / 773.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:2000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed:29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity)

Subcellular Localization：Mitochondrion outer membrane

Expression：
Tissue_Specificity: Strong expression in kidney and heart, and lower in liver and skeletal muscle
Induction: Up-regulated by fatty acids

Isoforms & Post-Translational Modification：P50416 has two isomers: P50416-1: 88368 Da (predicted); P50416-2: 86239 Da (predicted).

Subunit：Homohexamer and homotrimer (By similarity)

Synonyms

Carnitine O palmitoyltransferase 1 liver isoform antibody; Carnitine O palmitoyltransferase I antibody; Carnitine O palmitoyltransferase I liver isoform antibody; Carnitine O-palmitoyltransferase 1 antibody; Carnitine O-palmitoyltransferase I antibody; Carnitine palmitoyltransferase 1A (liver) antibody; Carnitine palmitoyltransferase 1A antibody; Carnitine palmitoyltransferase I antibody; Carnitine palmitoyltransferase I liver antibody; CPT 1 antibody; Carnitine O palmitoyltransferase 1 liver isoform antibody; Carnitine O palmitoyltransferase I antibody; Carnitine O palmitoyltransferase I liver isoform antibody; Carnitine O-palmitoyltransferase 1 antibody; Carnitine O-palmitoyltransferase I antibody; Carnitine palmitoyltransferase 1A (liver) antibody; Carnitine palmitoyltransferase 1A antibody; Carnitine palmitoyltransferase I antibody; Carnitine palmitoyltransferase I liver antibody; CPT 1 antibody; CPT I antibody; CPT1 antibody; CPT1 L antibody; CPT1-L antibody; Cpt1a antibody; CPT1A_HUMAN antibody; CPTI antibody; CPTI-L antibody; L CPT1 antibody; liver isoform antibody;

Documentation

User Guide for Antibodies (1077 KB)