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copper transport

" in MedChemExpress (MCE) Product Catalog:

標的別:	Antibiotic (2) Bacterial (5) Biochemical Assay Reagents (1) Cuproptosis (3) Drug Derivative (1) Environmental Pollutants (2) Fungal (3) Ligands for E3 Ligase (1) Mitochondrial Metabolism (1) p38 MAPK (1) PROTACs (1) Proton Pump (2) Reactive Oxygen Species (ROS) (1) Reference Standards (2)
研究分野別:	Cancer (6) Infection (3) Inflammation/Immunology (1) Metabolic Disease (3)

阻害剤およびアゴニスト

生化学アッセイ試薬

天然物

組換えタンパク質

抗体

Targets Recommended: FATP VAP-1

製品番号	製品名	Target	研究分野	構造式

HY-B0572

Zinc Pyrithione 10+ Cited Publications	Environmental Pollutants Bacterial Cuproptosis Proton Pump Fungal	Infection Metabolic Disease
Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump . Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis .

HY-B1005

8-Hydroxyquinoline 1 Publications Verification 8-Quinolinol	Environmental Pollutants Antibiotic Bacterial	Cancer
8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice .

HY-P2853

Hemocyanin	p38 MAPK Reactive Oxygen Species (ROS) Bacterial Fungal	Infection Inflammation/Immunology Cancer
Hemocyanin is an extracellular giant copper-containing glycoprotein. Hemocyanin can be found in the hemolymph of both mollusk and arthropod. Hemocyanin is responsible for oxygen transport. Hemocyanin is also involved in several physiological processes, such as energy storage, osmoregulation, molt cycle and exoskeleton formation. Hemocyanin in shrimp can enhance its immune response by modulating the p38 MAPK pathway. Hemocyanin from Penaeus monodon could act as an antiviral agent against a variety of viruses including DNA and RNA viruses. Hemocyanin from horseshoe crab Carcinoscorpius rotundicauda could possess a strong antimicrobial defense by the production of ROS activated with microbial proteases. Hemocyanin from L. vannamei would be effective against cervical cancer cell growth .

HY-162386

UM4118	Cuproptosis Mitochondrial Metabolism	Cancer
UM4118 is a potent copper-selective non-genotoxic copper ionophore that induces cuproptosis in acute myeloid leukemia cells. UM4118 exhibits stronger activity against SF3B1G12C mutant acute myeloid leukemia cells. UM4118 transports extracellular copper into cells, elevates intracellular and mitochondrial copper levels, and triggers lipoylated DLAT aggregation, proteotoxic stress, iron-sulfur cluster protein depletion, reduced lipoylated protein levels, and maximal mitochondrial respiratory damage. UM4118 cytotoxicity can be enhanced by supplementation with extracellular copper, abolished by copper chelation, and shows synthetic lethal effects in the absence of iron-sulfur cluster biosynthesis/transport genes. UM4118 can be used for the study of acute myeloid leukemia .

HY-120743

Triplin	Biochemical Assay Reagents	Metabolic Disease
Triplin is a copper chelator, Triplin perturbs copper ion transport involved in the interaction of RAN1 and ATX1. Triplin suppresses the toxic effects of excess copper ions on plant root growth. Triplin increases the RNA expression of ERF1. Triplin acts through the ethylene signal transduction pathway. Triplin also is a bacterial pore-former .

HY-B0572R

Zinc Pyrithione (Standard)	Reference Standards Cuproptosis Proton Pump Bacterial Fungal	Infection Metabolic Disease
Zinc Pyrithione (Standard) is the analytical standard of Zinc Pyrithione. This product is intended for research and analytical applications. Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump . Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis .

HY-B1005R

8-Hydroxyquinoline (Standard) 8-Quinolinol (Standard)	Reference Standards Bacterial Antibiotic	Cancer
8-Hydroxyquinoline (Standard) is the analytical standard of 8-Hydroxyquinoline. This product is intended for research and analytical applications. 8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice .

HY-147373

DA-PROTAC	PROTACs Ligands for E3 Ligase	Cancer
DA-PROTAC is a potent PROTAC degrader of copper ion-transport proteins Atox1 and CCS. DA-PROTAC can bind both Atox1 and CCS proteins, and the complex can be bound to E3 ligase, leading to increased levels of ubiquitination of Atox1 and CCS and degradation of Atox1 and CCS proteins via the proteasome pathway. DA-PROTAC can be used for triple negative breast cancer research .

HY-W051530

8-Methoxyquinoline	Drug Derivative	Cancer
8-Methoxyquinoline is a structural analogue of 8-hydroxyquinoline (HY-B1005). 8-Methoxyquinoline does not bind copper. 8-Methoxyquinoline could neither inhibit the chymotrypsin-like activity of the proteasome in breast cancer cell cultures nor induce cancer cell death. 8-Methoxyquinoline can be used in the research of breast cancer .

製品番号	製品名	Type

HY-P2853

Hemocyanin	生化学アッセイ試薬
Hemocyanin is an extracellular giant copper-containing glycoprotein. Hemocyanin can be found in the hemolymph of both mollusk and arthropod. Hemocyanin is responsible for oxygen transport. Hemocyanin is also involved in several physiological processes, such as energy storage, osmoregulation, molt cycle and exoskeleton formation. Hemocyanin in shrimp can enhance its immune response by modulating the p38 MAPK pathway. Hemocyanin from Penaeus monodon could act as an antiviral agent against a variety of viruses including DNA and RNA viruses. Hemocyanin from horseshoe crab Carcinoscorpius rotundicauda could possess a strong antimicrobial defense by the production of ROS activated with microbial proteases. Hemocyanin from L. vannamei would be effective against cervical cancer cell growth .

Hemocyanin

生化学アッセイ試薬

Hemocyanin is an extracellular giant copper-containing glycoprotein. Hemocyanin can be found in the hemolymph of both mollusk and arthropod. Hemocyanin is responsible for oxygen transport. Hemocyanin is also involved in several physiological processes, such as energy storage, osmoregulation, molt cycle and exoskeleton formation. Hemocyanin in shrimp can enhance its immune response by modulating the p38 MAPK pathway. Hemocyanin from Penaeus monodon could act as an antiviral agent against a variety of viruses including DNA and RNA viruses. Hemocyanin from horseshoe crab Carcinoscorpius rotundicauda could possess a strong antimicrobial defense by the production of ROS activated with microbial proteases. Hemocyanin from L. vannamei would be effective against cervical cancer cell growth .

製品番号	製品名	Category	Target	構造式

HY-P2853

Hemocyanin	Structural Classification 天然物 Animals Source Classification	p38 MAPK Reactive Oxygen Species (ROS) Bacterial Fungal
Hemocyanin is an extracellular giant copper-containing glycoprotein. Hemocyanin can be found in the hemolymph of both mollusk and arthropod. Hemocyanin is responsible for oxygen transport. Hemocyanin is also involved in several physiological processes, such as energy storage, osmoregulation, molt cycle and exoskeleton formation. Hemocyanin in shrimp can enhance its immune response by modulating the p38 MAPK pathway. Hemocyanin from Penaeus monodon could act as an antiviral agent against a variety of viruses including DNA and RNA viruses. Hemocyanin from horseshoe crab Carcinoscorpius rotundicauda could possess a strong antimicrobial defense by the production of ROS activated with microbial proteases. Hemocyanin from L. vannamei would be effective against cervical cancer cell growth .

Species:	Human (2)
Tag:	SUMO (1) His (2)
Source:	E. coli Cell-free (1) E. coli (1)

製品番号	Compare	製品名	Species	Source	Image

HY-P75585

	ATOX1 Protein, Human (His) copper transport protein ATOX1; Metal transport protein ATX1; HAH1	Human	E. coli
	ATOX1 Protein plays a crucial role in cellular copper transport, binding to and delivering cytosolic copper to copper ATPase proteins. This process is integral to cellular antioxidant defense mechanisms. ATOX1 functions as a homodimer, supported by research findings. It interacts with ATP7B and ATP7A. In its dimer form, ATOX1 interacts with SLC31A1, contributing to its stability and controlling intracellular Cu(I) levels. ATOX1 Protein, Human (His) is the recombinant human-derived ATOX1 protein, expressed by E. coli , with N-His labeled tag.

HY-P72011

	SLC31A1 Protein, Human (Cell-Free, His-SUMO) 1 Publications Verification copper transport 1 homolog; copper transporter 1; COPT1; COPT1_HUMAN; CTR1; hCTR1; High affinity copper uptake protein 1; SLC31A1; solute carrier family 31 copper tansporters; member 1; Solute carrier family 31 member 1	Human	E. coli Cell-free
	The SLC31A1 protein is an important uniporter that can transport copper(1+) from the extracellular space into the cytoplasm with remarkable specificity and deliver it directly to molecular chaperones such as ATOX1. This process tightly regulates intracellular copper(1+) levels and may be involved in intestinal copper absorption. SLC31A1 Protein, Human (Cell-Free, His-SUMO) is the recombinant human-derived SLC31A1 protein, expressed by E. coli Cell-free , with N-SUMO, N-6*His labeled tag.

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HY-P86777

	ATOX1 Antibody (YA6470) ATOX1 antibody; ATOX1_HUMAN antibody; ATX1 antibody; ATX1 antioxidant protein 1 homolog (yeast) antibody; ATX1 antioxidant protein 1 homolog antibody; copper transport protein antibody; copper transport protein ATOX1 antibody; HAH1 antibody; Metal transport protein antibody; Metal transport protein ATX1 antibody; ATOX1 antibody; ATOX1_HUMAN antibody; ATX1 antibody; ATX1 antioxidant protein 1 homolog (yeast) antibody; ATX1 antioxidant protein 1 homolog antibody; copper transport protein antibody; copper transport protein ATOX1 antibody; HAH1 antibody; Metal transport protein antibody; Metal transport protein ATX1 antibody; MGC138453 antibody; MGC138455 antibody;	WB, ICC/IF, IHC-P, FC	Human
	ATOX1 Antibody (YA6470) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATOX1.

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