2. MAPK/ERK Pathway NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Anti-infection
  3. p38 MAPK Reactive Oxygen Species (ROS) Bacterial Fungal
  4. Hemocyanin

Hemocyanin is an extracellular giant copper-containing glycoprotein. Hemocyanin can be found in the hemolymph of both mollusk and arthropod. Hemocyanin is responsible for oxygen transport. Hemocyanin is also involved in several physiological processes, such as energy storage, osmoregulation, molt cycle and exoskeleton formation. Hemocyanin in shrimp can enhance its immune response by modulating the p38 MAPK pathway. Hemocyanin from Penaeus monodon could act as an antiviral agent against a variety of viruses including DNA and RNA viruses. Hemocyanin from horseshoe crab Carcinoscorpius rotundicauda could possess a strong antimicrobial defense by the production of ROS activated with microbial proteases. Hemocyanin from L. vannamei would be effective against cervical cancer cell growth.

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Hemocyanin

Hemocyanin Chemical Structure

CAS No. : 9013-72-3

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Hemocyanin Related Antibodies

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Description

Hemocyanin is an extracellular giant copper-containing glycoprotein. Hemocyanin can be found in the hemolymph of both mollusk and arthropod. Hemocyanin is responsible for oxygen transport. Hemocyanin is also involved in several physiological processes, such as energy storage, osmoregulation, molt cycle and exoskeleton formation. Hemocyanin in shrimp can enhance its immune response by modulating the p38 MAPK pathway. Hemocyanin from Penaeus monodon could act as an antiviral agent against a variety of viruses including DNA and RNA viruses. Hemocyanin from horseshoe crab Carcinoscorpius rotundicauda could possess a strong antimicrobial defense by the production of ROS activated with microbial proteases. Hemocyanin from L. vannamei would be effective against cervical cancer cell growth[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Hemocyanin (10-50 μg/mL; 48 h) from Litopenaeus vannamei exhibits antiproliferative activity against HeLa cells (57-71% inhibition)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hemocyanin Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HeLa cells, 293T cells
Concentration: 10, 20, 30, 40, 50 μg/mL
Incubation Time: 24 h, 48 h
Result: Inhibited HeLa cell growth by 57-71% at 10-50 μg/mL for 48 h (p < 0.01). Showed no significant growth inhibition in 293T cells under the same conditions.
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

[Hemocyanin]
Structure Classification
Initial Source

crayfish
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

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Purity & Documentation

Purity: 95%

SDS (251 KB)

COA (230 KB)

Handling Instructions (2659 KB)
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Hemocyanin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hemocyanin9013-72-3p38 MAPKReactive Oxygen Species (ROS)BacterialFungalVibrio spp.caspase-3Litopenaeus vannamei293T cellsp38-MAPK-c-Jun signaling pathwaytype-3 copper centerVibrio parahaemolyticusmitochondria-mediated apoptotic pathwayHeLa cellscaspase-9Inhibitorinhibitorinhibit

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