8-Methoxyquinoline 

8-Methoxyquinoline is a structural analogue of 8-hydroxyquinoline (HY-B1005). 8-Methoxyquinoline does not bind copper. 8-Methoxyquinoline could neither inhibit the chymotrypsin-like activity of the proteasome in breast cancer cell cultures nor induce cancer cell death. 8-Methoxyquinoline can be used in the research of breast cancer^[1].

8-Methoxyquinoline (10 μM; 1-2 h) does not facilitate copper transport into DCIS cells when mixed with CuCl₂^[1].
8-Methoxyquinoline-CuCl₂ mixtures (1.0-20.0 μM; 24 h) has much less growth-
inhibitory effect in contrast to that of 8-hydroxyquinoline-CuCl2 in DCIS cells^[1].
8-Methoxyquinoline-CuCl₂ mixtures (1.0-5.0 μM; 8-12 h) do not inhibit proteasomal CT-like activity in DCIS cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

159.18

C₁₀H₉NO

938-33-0

Solid

COC1=CC=CC2=C1N=CC=C2

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

• [1]. Zhai S, et al. Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells. J Biol Inorg Chem. 2010;15(2):259-269.  [Content Brief]