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decorin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RAR/RXR (1)
By Research Areas:	Inflammation/Immunology (1) Neurological Disease (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111573

KCL-286 C286	RAR/RXR	Others Neurological Disease Inflammation/Immunology
KCL-286 (C286) is an orally active and brain-penetrant retinoic acid receptor (RAR) β2 agonist (EC₅₀ = 1.9 nM). KCL-286 targets RARβ2 with good selectivity over RAR α (EC₅₀ = 26 nM) and RAR γ (EC₅₀ = 11 nM). KCL-286 activates RARβ2 in the injured neurons. KCL-286 induces axonal regeneration of both spinal and sensory nerves through the inhibitory environment of the CNS, modulates neuroinflammation and extracellular matrix molecules. KCL-286 can modulate the expression of CSPGs by neuronal secretion of decorin which promotes myelination and aids axonal growth. KCL-286 can be studied in research for area such as spinal cord injury and traumatic nerve injury .

Species:	Human (1) Mouse (1) Rat (1) Bovine (1)
Tag:	His (4)
Source:	HEK293 (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704181

	Decorin/PGS2 Protein, Bovine (His) rMudecorin/PGS2, His; decorin; Bone proteoglycan II; PG-S2; PG40; Dcn	Bovine	E. coli
	Decorin/PGS2 Protein, Bovine (His) is the recombinant bovine-derived Decorin/PGS2 protein, expressed by E. coli, with N-6*His tag.

HY-P74202

	Decorin/PGS2 Protein, Rat (HEK293, His) 1 Publications Verification decorin; Bone proteoglycan II; PG-S2; PG40; DCN; SLRR1B	Rat	HEK293
	Decorin/PGS2 protein is involved in regulating extracellular matrix dynamics, affecting the rate of fibril formation and participating in rat cervical dilation. It has versatile binding properties, interacting with type I and type II collagen, fibronectin, and TGF-β, suggesting involvement in a variety of cellular processes. Decorin/PGS2 Protein, Rat (HEK293, His) is the recombinant rat-derived Decorin/PGS2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70021

	Decorin/PGS2 Protein, Mouse (HEK293, His) rMudecorin/PGS2, His; decorin; Bone proteoglycan II; PG-S2; PG40; Dcn	Mouse	HEK293
	Decorin/PGS2 protein, influencing fibril formation rate, binds strongly to type I and type II collagen, fibronectin, and TGF-beta. It participates in extracellular matrix organization by forming a ternary complex with MFAP2 and ELN, and interacts with DPT, potentially modulating matrix assembly and structure. Decorin/PGS2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Decorin/PGS2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7885

	Decorin/PGS2 Protein, Human (HEK293, His) 1 Publications Verification rHudecorin/PGS2, His; decorin; Bone proteoglycan II; PG-S2; PG40; DCN; SLRR1B	Human	HEK293
	Decorin/PGS2 Protein, Human (HEK 293, His) expresses in HEK293 with a His tag at the N-terminus. Decorin, an extracellular matrix (ECM) protein, belongs to the small leucine-rich proteoglycan family. Decorin acts as a ligand of various cytokines and growth factors by directly or indirectly interacting with the corresponding signalling molecules involved in cell growth, differentiation, proliferation, adhesion and metastasis.

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Host:	Mouse (1) Rabbit (1)
Reactivity:	Human (1) mouse (1) Rat (1) Mouse (1)
Application:	IHC-P (1) ICC/IF (1) IF-Tissue (1) IP (1) WB (2) ELISA (1)
Isotype:	IgG (1) IgG1 (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (2)

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HY-P810192

	Decorin Antibody (YA9536)	WB, ICC/IF, IF-Tissue, IP, ELISA	mouse
	Decorin Antibody (YA9536) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Decorin.

HY-P87193

	Decorin Antibody (YA6881) Bone proteoglycan II antibody	WB, IHC-P	Human, Mouse, Rat
	Decorin Antibody (YA6881) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Decorin.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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