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dendrite growth

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By Targets:	Biochemical Assay Reagents (2) Drug Intermediate (1) HDAC (1) IFNAR (1) P2X Receptor (1) ROCK (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1) Neurological Disease (2)
Oligonucleotides:	Nucleotide Analogs (1) Adenine Nucleotide (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Oligonucleotides

Targets Recommended: FGFR GHR VEGFR TGF-β Receptor PDGFR EGFR IGF-1R GHSR TGF-beta/Smad Nuclear Hormone Receptor 4A/NR4A

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113273A

Diadenosine pentaphosphate pentasodium	P2X Receptor	Neurological Disease
Diadenosine pentaphosphate pentasodium is an agonist and negative modulator of the P2X1 receptor, an endogenous vasoactive purine dinucleotide that can be isolated from platelets. Diadenosine pentaphosphate pentasodium mediates negative regulation of dendrite growth and number by activating homologous and heterologous P2X1 receptors, which triggers a transient and moderate increase in intracellular calcium levels within dendritic growth cones. Diadenosine pentaphosphate pentasodium is widely present in secretory vesicles such as platelets, chromaffin cells and brain synaptosomes, and exhibits selective activity on dendrite growth of cultured hippocampal neurons, inhibiting only dendrite growth without affecting axon growth. Diadenosine pentaphosphate pentasodium has a weaker ability to compete with RcCHAD for binding to polyP than short-chain polyPs .

HY-40145

1-Boc-3-iodoazetidine	Drug Intermediate	Others
1-Boc-3-iodoazetidine acts as a bifunctional additive for lithium-oxygen (Li-O₂) batteries and can be used to enhance the performance of Li-O₂ batteries. 1-Boc-3-iodoazetidine is applied in the synthesis of C3-functionalized azetidines and C2-functionalized azetidines via a lithium/iodine exchange or β-elimination/lithiation reaction sequence .

HY-156422

KPZ560	HDAC	Neurological Disease Cancer
KPZ560 is a potent inhibitor of HDAC1 and HDAC2, with IC₅₀s of 12 nM and 68 nM, respectively. KPZ560 can increase in the spine density of granule neuron dendrites of mice and inhibitor cell growth of breast cancer cell line MCF .

HY-N10341

Centaureidin	IFNAR ROCK	Inflammation/Immunology Cancer
Centaureidin is an orally active IFN-promoter that can be isolated from Bidens pilosa with an EC₅₀ of 0.9 μg/mL. Centaureidin activates the Rho signal pathway, leading to actin and tubulin disassembly, and resulting in dendrite retraction and stress fiber formation in melanocytes. Centaureidin shows high tumor cell growth inhibitory activities. Centaureidin significantly inhibits paw edema in mice ^{[1][2][3][4][5]}.

HY-Y1890B

Cremophor EL-10	Biochemical Assay Reagents	Others
Cremophor EL-10 is a nonionic polyoxyethylene castor oil surfactant with multiple functions including organic solubilizer, mixed zinc anode corrosion inhibitor and dendrite growth inhibitor. By forming a physical barrier to block electrolyte contact and constructing oriented hydration channels to reduce the desolvation energy barrier of Zn ²⁺, Cremophor EL-10 achieves a corrosion inhibition efficiency of over 99%. Cremophor EL-10 exerts no significant effects on the mitochondrial activity and cell viability of epithelial cells, making it suitable for in vitro drug delivery and biopharmaceutical research at concentrations ≤10% v/v. However, Cremophor EL-10 may induce sustained non-endothelium-dependent contraction in rat aortic rings and exert concentration-dependent inhibitory effects on acetylcholine-induced endothelium-dependent relaxation responses .

HY-21170E

Zinc trifluoromethanesulfonate Zinc(II) Triflate	Biochemical Assay Reagents	Others
Zinc trifluoromethanesulfonate (Zinc (II) Triflate) is a Zn ²⁺ salt commonly used in potentiometric titration to determine the stability constants of Zn ²⁺-quinoline sulfonamide complexes. Aqueous solutions of Zinc trifluoromethanesulfonate form micellar structures, which result in poor desolvation kinetics of Zn ²⁺ and induce dendrite growth on zinc anodes, failing to support long-term cycling of zinc anodes .

Cat. No.	Product Name	Type

HY-40145

1-Boc-3-iodoazetidine	Biochemical Assay Reagents
1-Boc-3-iodoazetidine acts as a bifunctional additive for lithium-oxygen (Li-O₂) batteries and can be used to enhance the performance of Li-O₂ batteries. 1-Boc-3-iodoazetidine is applied in the synthesis of C3-functionalized azetidines and C2-functionalized azetidines via a lithium/iodine exchange or β-elimination/lithiation reaction sequence .

HY-Y1890B

Cremophor EL-10	Biochemical Assay Reagents
Cremophor EL-10 is a nonionic polyoxyethylene castor oil surfactant with multiple functions including organic solubilizer, mixed zinc anode corrosion inhibitor and dendrite growth inhibitor. By forming a physical barrier to block electrolyte contact and constructing oriented hydration channels to reduce the desolvation energy barrier of Zn ²⁺, Cremophor EL-10 achieves a corrosion inhibition efficiency of over 99%. Cremophor EL-10 exerts no significant effects on the mitochondrial activity and cell viability of epithelial cells, making it suitable for in vitro drug delivery and biopharmaceutical research at concentrations ≤10% v/v. However, Cremophor EL-10 may induce sustained non-endothelium-dependent contraction in rat aortic rings and exert concentration-dependent inhibitory effects on acetylcholine-induced endothelium-dependent relaxation responses .

Cremophor EL-10

Biochemical Assay Reagents

Cremophor EL-10 is a nonionic polyoxyethylene castor oil surfactant with multiple functions including organic solubilizer, mixed zinc anode corrosion inhibitor and dendrite growth inhibitor. By forming a physical barrier to block electrolyte contact and constructing oriented hydration channels to reduce the desolvation energy barrier of Zn ²⁺, Cremophor EL-10 achieves a corrosion inhibition efficiency of over 99%. Cremophor EL-10 exerts no significant effects on the mitochondrial activity and cell viability of epithelial cells, making it suitable for in vitro drug delivery and biopharmaceutical research at concentrations ≤10% v/v. However, Cremophor EL-10 may induce sustained non-endothelium-dependent contraction in rat aortic rings and exert concentration-dependent inhibitory effects on acetylcholine-induced endothelium-dependent relaxation responses .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10341

Centaureidin	Flavonoids Flavones Tanacetum microphyllum DC. Plants Compositae Source Classification	IFNAR ROCK
Centaureidin is an orally active IFN-promoter that can be isolated from Bidens pilosa with an EC₅₀ of 0.9 μg/mL. Centaureidin activates the Rho signal pathway, leading to actin and tubulin disassembly, and resulting in dendrite retraction and stress fiber formation in melanocytes. Centaureidin shows high tumor cell growth inhibitory activities. Centaureidin significantly inhibits paw edema in mice ^{[1][2][3][4][5]}.

Cat. No.	Product Name		Classification

HY-113273A

Diadenosine pentaphosphate pentasodium		Nucleotide Analogs Adenine Nucleotide
Diadenosine pentaphosphate pentasodium is an agonist and negative modulator of the P2X1 receptor, an endogenous vasoactive purine dinucleotide that can be isolated from platelets. Diadenosine pentaphosphate pentasodium mediates negative regulation of dendrite growth and number by activating homologous and heterologous P2X1 receptors, which triggers a transient and moderate increase in intracellular calcium levels within dendritic growth cones. Diadenosine pentaphosphate pentasodium is widely present in secretory vesicles such as platelets, chromaffin cells and brain synaptosomes, and exhibits selective activity on dendrite growth of cultured hippocampal neurons, inhibiting only dendrite growth without affecting axon growth. Diadenosine pentaphosphate pentasodium has a weaker ability to compete with RcCHAD for binding to polyP than short-chain polyPs .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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dendrite growth

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Oligonucleotides

Natural
Products