Diadenosine pentaphosphate pentasodium
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Diadenosine pentaphosphate pentasodium is an agonist and negative modulator of the P2X1 receptor, an endogenous vasoactive purine dinucleotide that can be isolated from platelets. Diadenosine pentaphosphate pentasodium mediates negative regulation of dendrite growth and number by activating homologous and heterologous P2X1 receptors, which triggers a transient and moderate increase in intracellular calcium levels within dendritic growth cones. Diadenosine pentaphosphate pentasodium is widely present in secretory vesicles such as platelets, chromaffin cells and brain synaptosomes, and exhibits selective activity on dendrite growth of cultured hippocampal neurons, inhibiting only dendrite growth without affecting axon growth. Diadenosine pentaphosphate pentasodium has a weaker ability to compete with RcCHAD for binding to polyP than short-chain polyPs.
For research use only. We do not sell to patients.
- Purity: 99.13%
- CAS No.: 4097-04-5
- Formula: C20H24N10Na5O22P5
- Molecular Weight:1026.28
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All P2X Receptor Isoforms
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Biological Activity
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p2x1 Receptor |
Diadenosine pentaphosphate pentasodium (30 μM; 5 min+15 min) inhibits adenylate kinase activity in mitochondria isolated from wheat (Triticum aestivum v. Westonia), thereby enabling the specific detection of ATP synthase-dependent ATP synthesis[1].
Diadenosine pentaphosphate pentasodium (100 μM; 72 h) reduces the total dendritic length and number of dendrites in E18 mouse hippocampal neurons cultured in a phenol red-free system; this effect is blocked by treatment with 10 nM NF449 (HY-112461) or 10 nM Ip5I, but not by 20 nM NF279 (HY-D0976)[3].
Diadenosine pentaphosphate pentasodium (100 μM; 72 h) induces reductions in dendritic length and number in E18 mouse hippocampal neurons cultured in phenol red-free medium, and this effect is blocked by pretreatment with 10 nM TNP-ATP[3].
Diadenosine polyphosphates (ApnA, n=2-7) are identified as components of secretory vesicles, such as platelets, chromaffin cells, Torpedo nerve terminals and brain synaptosomes[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:E18 mouse hippocampal neurons
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Concentration:100 μM; with or without 10 nM NF449 or 10 nM Ip5I
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Incubation Time:72 h
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Result:Reduceed total dendrite length by 28.7% and dendrite number by 28.1% in phenol red-free cultures of E18 mouse hippocampal neurons after 72 h of incubation, with no effect on axonal length.
Blocked by pre-treatment with 10 nM NF449 (HY-112461) or 10 nM Ip5I, but not by 20 nM NF279 (HY-D0976).
Chemical Information
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CAS No. 4097-04-5
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Appearance Solid
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Molecular Weight 1026.28
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Formula C20H24N10Na5O22P5
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]1COP(OP(OP(OP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C6=NC=NC(N)=C6N=C5)O4)(O[Na])=O)(O[Na])=O)(O[Na])=O)(O[Na])=O)(O[Na])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 87.5 mg/mL (85.26 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Jacoby RP, et al. Analysis of the sodium chloride-dependent respiratory kinetics of wheat mitochondria reveals differential effects on phosphorylating and non-phosphorylating electron transport pathways. Plant Cell Environ. 2016;39(4):823-833. [Content Brief]
[2]. Lorenzo-Orts L, et al. Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules. Life Sci Alliance. 2019;2(3):e201900385. Published 2019 May 27. [Content Brief]
[3]. Diez-Zaera M, et al. Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons. Purinergic Signal. 2024;20(2):115-125. [Content Brief]
[4]. L Giraldez, et al. Adenosine triphosphate and diadenosine pentaphosphate induce [Ca(2+)](i) increase in rat basal ganglia aminergic terminals. J Neurosci Res. 2001 Apr 15;64(2):174-82. [Content Brief]
[5]. Jesús Pintor, et al. Presence of diadenosine polyphosphates in human tears. Pflugers Arch. 2002 Jan;443(3):432-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.9744 mL | 4.8720 mL | 9.7439 mL | 24.3598 mL |
| 5 mM | 0.1949 mL | 0.9744 mL | 1.9488 mL | 4.8720 mL | |
| 10 mM | 0.0974 mL | 0.4872 mL | 0.9744 mL | 2.4360 mL | |
| 15 mM | 0.0650 mL | 0.3248 mL | 0.6496 mL | 1.6240 mL | |
| 20 mM | 0.0487 mL | 0.2436 mL | 0.4872 mL | 1.2180 mL | |
| 25 mM | 0.0390 mL | 0.1949 mL | 0.3898 mL | 0.9744 mL | |
| 30 mM | 0.0325 mL | 0.1624 mL | 0.3248 mL | 0.8120 mL | |
| 40 mM | 0.0244 mL | 0.1218 mL | 0.2436 mL | 0.6090 mL | |
| 50 mM | 0.0195 mL | 0.0974 mL | 0.1949 mL | 0.4872 mL | |
| 60 mM | 0.0162 mL | 0.0812 mL | 0.1624 mL | 0.4060 mL | |
| 80 mM | 0.0122 mL | 0.0609 mL | 0.1218 mL | 0.3045 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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