4097-04-5
Chemical Structure
Diadenosine pentaphosphate pentasodium
Synonym(s): Ap5A pentasodium; P1,P5-Di(adenosine-5'-)pentaphosphate pentasodium
- CAS No.: 4097-04-5
- Formula:C20H24N10Na5O22P5
- Molecular Weight:1026.28
InChIKey: NNMFUJJMJIYTSP-CSMIRWGRSA-I
SMILES: O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]1COP(OP(OP(OP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C6=NC=NC(N)=C6N=C5)O4)(O[Na])=O)(O[Na])=O)(O[Na])=O)(O[Na])=O)(O[Na])=O
Biological Activity: Diadenosine pentaphosphate (Ap5A; P1,P5-Di(adenosine-5'-)pentaphosphate) pentasodium is an endogenous generated diadenosine polyphosphate, possessing the dual identities of intracellular alarm signal and extracellular signaling molecule. Diadenosine pentaphosphate regulates calcium signaling in the nervous, cardiac and peripheral sensory systems by activating P2X1/P2X3/P2Y receptor and RyR2 channels (EC50 = 140 μM). Diadenosine pentaphosphate can be used in studies related to intracellular calcium release channels, cardiovascular diseases and nociception (pain)[1][3][2][4][5].
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Diadenosine pentaphosphate pentasodium | 99.13% | Diadenosine pentaphosphate (Ap5A; P1,P5-Di(adenosine-5'-)pentaphosphate) pentasodium is an endogenous generated diadenosine polyphosphate, possessing the dual identities of intracellular alarm signal and extracellular signaling molecule. Diadenosine pentaphosphate regulates calcium signaling in the nervous, cardiac and peripheral sensory systems by activating P2X1/P2X3/P2Y receptor and RyR2 channels (EC50 = 140 μM). Diadenosine pentaphosphate can be used in studies related to intracellular calcium release channels, cardiovascular diseases and nociception (pain). | ||||||||||||||||||||
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- [1]. Jacoby RP, et al. Analysis of the sodium chloride-dependent respiratory kinetics of wheat mitochondria reveals differential effects on phosphorylating and non-phosphorylating electron transport pathways. Plant Cell Environ. 2016;39(4):823-833. [Content Brief]
- [2]. Lorenzo-Orts L, et al. Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules. Life Sci Alliance. 2019;2(3):e201900385. Published 2019 May 27. [Content Brief]
- [3]. Diez-Zaera M, et al. Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons. Purinergic Signal. 2024;20(2):115-125. [Content Brief]
- [4]. L Giraldez, et al. Adenosine triphosphate and diadenosine pentaphosphate induce [Ca(2+)](i) increase in rat basal ganglia aminergic terminals. J Neurosci Res. 2001 Apr 15;64(2):174-82. [Content Brief]
- [5]. Jesús Pintor, et al. Presence of diadenosine polyphosphates in human tears. Pflugers Arch. 2002 Jan;443(3):432-6. [Content Brief]
