Ap4A
Ap4A (P1,P4-Di-(adenosine-5')-tetraphosphate) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A induces apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 5542-28-9
- Formula: C20H28N10O19P4
- Molecular Weight:836.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ap4A (1, 10 µM; 24 h) induces apoptosis in HL60 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL60 cells
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Concentration:1, 10 µM
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Incubation Time:24 h
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Result:Induced apoptosis with the proportion of apoptotic cells reached 24±2% of the total cell number after incubation for 24 h.
Chemical Information
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CAS No. 5542-28-9
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Molecular Weight 836.39
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Formula C20H28N10O19P4
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OP(OP(OC[C@H]4O[C@@H](N5C=NC6=C5N=CN=C6N)[C@H](O)[C@@H]4O)(O)=O)(O)=O)(O)=O)(O)=O
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Synonyms
P1,P4-Di-(adenosine-5')-tetraphosphate
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yu J, et al. Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells. Nat Commun. 2019 Oct 11;10(1):4664. [Content Brief]
[2]. Vartanian A, et al. Ap4A induces apoptosis in human cultured cells. FEBS Lett. 1999 Jul 30;456(1):175-80. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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