Ap4A tetraammonium
Based on 1 Customer Validation
Ap4A tetraammonium (P1,P4-Di-(adenosine-5')-tetraphosphate tetraammonium) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A tetraammonium binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A tetraammonium induces apoptosis.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 102783-36-8
- Formula: C20H40N14O19P4
- Molecular Weight:904.51
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Apoptosis Compound Library
HY-L003
-
Anti-Cancer Compound Library
HY-L025
-
Antibacterial Compound Library
HY-L049
-
Transcription Factor-Targeted Library
HY-L090
-
Cell Death Library
HY-L162
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
High-Throughput Bioactive Compound Library
HY-L205
-
Nucleotide Metabolite Compound Library
HY-L234
Biological Activity
Chemical Information
-
CAS No. 102783-36-8
-
Appearance Solid
-
Molecular Weight 904.51
-
Formula C20H40N14O19P4
-
Color White to off-white
-
SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OP(OP(OC[C@H]4O[C@@H](N5C=NC6=C5N=CN=C6N)[C@H](O)[C@@H]4O)(O)=O)(O)=O)(O)=O)(O)=O.N.N.N.N
-
Synonyms
P1,P4-Di-(adenosine-5')-tetraphosphate tetraammonium
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (110.56 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Yu J, et al. Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells. Nat Commun. 2019 Oct 11;10(1):4664. [Content Brief]
[2]. Vartanian A, et al. Ap4A induces apoptosis in human cultured cells. FEBS Lett. 1999 Jul 30;456(1):175-80. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.1056 mL | 5.5279 mL | 11.0557 mL | 27.6393 mL |
| 5 mM | 0.2211 mL | 1.1056 mL | 2.2111 mL | 5.5279 mL | |
| 10 mM | 0.1106 mL | 0.5528 mL | 1.1056 mL | 2.7639 mL | |
| 15 mM | 0.0737 mL | 0.3685 mL | 0.7370 mL | 1.8426 mL | |
| 20 mM | 0.0553 mL | 0.2764 mL | 0.5528 mL | 1.3820 mL | |
| 25 mM | 0.0442 mL | 0.2211 mL | 0.4422 mL | 1.1056 mL | |
| 30 mM | 0.0369 mL | 0.1843 mL | 0.3685 mL | 0.9213 mL | |
| 40 mM | 0.0276 mL | 0.1382 mL | 0.2764 mL | 0.6910 mL | |
| 50 mM | 0.0221 mL | 0.1106 mL | 0.2211 mL | 0.5528 mL | |
| 60 mM | 0.0184 mL | 0.0921 mL | 0.1843 mL | 0.4607 mL | |
| 80 mM | 0.0138 mL | 0.0691 mL | 0.1382 mL | 0.3455 mL | |
| 100 mM | 0.0111 mL | 0.0553 mL | 0.1106 mL | 0.2764 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Powered by Bioz