1-Boc-3-iodoazetidine
Based on 1 Customer Validation
1-Boc-3-iodoazetidine acts as a bifunctional additive for lithium-oxygen (Li-O2) batteries and can be used to enhance the performance of Li-O2 batteries. 1-Boc-3-iodoazetidine is applied in the synthesis of C3-functionalized azetidines and C2-functionalized azetidines via a lithium/iodine exchange or β-elimination/lithiation reaction sequence.
For research use only. We do not sell to patients.
- Purity: 98.97%
- CAS No.: 254454-54-1
- Formula: C8H14INO2
- Molecular Weight:283.11
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1-Boc-3-iodoazetidine can form lithium iodide and lithium-based organometallic protective layers on the surface of lithium metal, maintain a flat, dendrite-free surface of the lithium anode after 60 cycles, and prevent the pores of the cathode from being blocked[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 254454-54-1
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Appearance Liquid (Density: 1.63 g/cm3)
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Molecular Weight 283.11
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Formula C8H14INO2
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Color Light yellow to yellow
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SMILES
O=C(N1CC(C1)I)OC(C)(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (353.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.83 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.83 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
[1]. Li YN, et al. Bifunctional 1-Boc-3-Iodoazetidine Enhancing Lithium Anode Stability and Rechargeability of Lithium-Oxygen Batteries. ACS Appl Mater Interfaces. 2021;13(14):16437-16444. [Content Brief]
[2]. Colella M, et al. Development of a Continuous Flow Synthesis of 2-Substituted Azetines and 3-Substituted Azetidines by Using a Common Synthetic Precursor. J Org Chem. 2021;86(20):13943-13954. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5322 mL | 17.6610 mL | 35.3220 mL | 88.3049 mL |
| 5 mM | 0.7064 mL | 3.5322 mL | 7.0644 mL | 17.6610 mL | |
| 10 mM | 0.3532 mL | 1.7661 mL | 3.5322 mL | 8.8305 mL | |
| 15 mM | 0.2355 mL | 1.1774 mL | 2.3548 mL | 5.8870 mL | |
| 20 mM | 0.1766 mL | 0.8830 mL | 1.7661 mL | 4.4152 mL | |
| 25 mM | 0.1413 mL | 0.7064 mL | 1.4129 mL | 3.5322 mL | |
| 30 mM | 0.1177 mL | 0.5887 mL | 1.1774 mL | 2.9435 mL | |
| 40 mM | 0.0883 mL | 0.4415 mL | 0.8830 mL | 2.2076 mL | |
| 50 mM | 0.0706 mL | 0.3532 mL | 0.7064 mL | 1.7661 mL | |
| 60 mM | 0.0589 mL | 0.2943 mL | 0.5887 mL | 1.4717 mL | |
| 80 mM | 0.0442 mL | 0.2208 mL | 0.4415 mL | 1.1038 mL | |
| 100 mM | 0.0353 mL | 0.1766 mL | 0.3532 mL | 0.8830 mL |
1-Boc-3-iodoazetidine Related Classifications
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