42 Results for "

deuterated form

" in MedChemExpress (MCE) Product Catalog:
Products (42)

42 Results for "deuterated form" in MCE Product Catalog:

2
Phenylacetylglutamine-d5
Phenylacetylglutamine-d5
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2 Cited Publications
Cat. No.: HY-W050026S
CAS No.: 1331909-01-3
Synonyms: NSC 203800-d5; Phenylacetyl-L-glutamine-d5
Phenylacetylglutamine-d5 (NSC 203800-d5) is the deuterium labeled Phenylacetylglutamine (HY-W050026). Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation .
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L-Valine-d8
L-Valine-d8
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1 Cited Publications
Cat. No.: HY-I1124
CAS No.: 35045-72-8
Synonyms: L-VALINE-2,3,4,4,4,5,5,5-d8
L-Valine-d8 is a deuterated form of L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase .
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Tacrolimus-13C,d2
Tacrolimus-13C,d2
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1 Cited Publications
Cat. No.: HY-13756S
CAS No.: 1356841-89-8
Purity:  98.36%
Synonyms: FK506-13C,d2; Fujimycin-13C,d2; FR900506-13C,d2
Tacrolimus- 13C,d2 (FK506- 13C,d2) is the 13C, deuterated-labeled Tacrolimus (HY-13756). Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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MMAF-d8 hydrochloride
MMAF-d8 hydrochloride
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1 Cited Publications
Cat. No.: HY-15579AS
Purity:  99.70%
MMAF-d8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
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Maxacalcitol-d6
Maxacalcitol-d6
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1 Cited Publications
Cat. No.: HY-15329
CAS No.: 2070009-38-8
Purity:  99.63%
Maxacalcitol-d66 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.
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Thiabendazole-d4
Thiabendazole-d4
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Cat. No.: HY-B0263S
CAS No.: 1190007-20-5
Synonyms: 2-(4-Thiazolyl)benzimidazole-d4
Thiabendazole-d4 is a deuterated form of Thiabendazole, which is an antiseptic, antifungal and antiparasitic agent .
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Bupropion morpholinol-d6
Bupropion morpholinol-d6
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Cat. No.: HY-12766S
CAS No.: 1216893-18-3
Purity:  99.28%
Bupropion morpholinol-d6 is the deuterated form of Bupropion morpholinol. Bupropion morpholinol is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities .
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Salcaprozate-d4 sodium
Salcaprozate-d4 sodium
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Cat. No.: HY-114299S
Synonyms: SNAC-d4 sodium
Salcaprozate-d4 (sodium) is a deuterated labeled Salcaprozate (sodium) . Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation .
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DL-Dithiothreitol-d6
DL-Dithiothreitol-d6
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Cat. No.: HY-15917S2
CAS No.: 850153-85-4
Synonyms: DTT-d6
DL-Dithiothreitol-d6 is the deuterated form of DL-Dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond .
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Cereulide-13C6
Cereulide-13C6
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Cat. No.: HY-P3003S
CAS No.: 1487375-69-8
Cereulide- 13C6 is a deuterated form of Cereulide. Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K +, and transports K + from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning.
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Tacrolimus-d3
Tacrolimus-d3
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Cat. No.: HY-13756S2
Synonyms: FK506-d3; Fujimycin-d3; FR900506-d3
Tacrolimus-d3 (FK506-d3) is the deuterated-labeled Tacrolimus (HY-13756). Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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(R)-(+)-Warfarin-d5
(R)-(+)-Warfarin-d5
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Cat. No.: HY-W015998S
CAS No.: 773005-79-1
(R)-(+)-Warfarin-d5 is the deuterated-labeled (R)-(+)-Warfarin (HY-W015998). (R)-(+)-Warfarin is an orally active chiral 4-hydroxycoumarin compound with vitamin K epoxide reductase (VKOR) inhibitory activity and cytochrome P450 substrate activity . (R)-(+)-Warfarin undergoes stereoselective metabolism via CYP1A2 to form 6-Hydroxywarfarin and 8-Hydroxywarfarin, and is metabolized via CYP3A4 to produce 10-Hydroxywarfarin (HY-134999). (R)-(+)-Warfarin can be used for the research of thromboembolic diseases .
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9-cis-Retinol-d5
9-cis-Retinol-d5
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Cat. No.: HY-W654334
9-cis-Retinol-d5 is the deuterated-labeled 9-cis Retinol (HY-W587806). 9-cis Retinol is an upstream precursor of 9-cis-Retinal (HY-W009310) and 9-cis-Retinoic acid (HY-15128). 9-cis Retinol serves as a reaction substrate for cRDH, ARAT and LRAT, participates in cellular uptake and isomerization processes, and can be oxidized to form 9-cis-Retinal in the biosynthetic pathway. 9-cis Retinol inhibits the activity of 9-cis retinaldehyde dehydrogenase, thereby blocking the biosynthesis of 9-cis-Retinoic acid. 9-cis Retinol is applicable for metabolism-related research .
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N-Acetyl-L-tyrosine-d3
N-Acetyl-L-tyrosine-d3
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Cat. No.: HY-W012382S
N-Acetyl-L-tyrosine-d3 is the deuterated form of N-Acetyl-L-tyrosine (HY-W012382). N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .
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Liothyronine-d3
Liothyronine-d3
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Cat. No.: HY-A0070AS3
Synonyms: Triiodothyronine-d3; 3,3',5-Triiodo-L-thyronine-d3; T3-d3
Liothyronine-d3 is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively .
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DL-Dithiothreitol-d10
DL-Dithiothreitol-d10
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Cat. No.: HY-15917S
CAS No.: 302912-05-6
Synonyms: DTT-d10
DL-Dithiothreitol-d10 is the deuterated form of DL-Dithiothreitol. DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond .
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Hexadecylpyridinium-d5 bromide
Hexadecylpyridinium-d5 bromide
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Cat. No.: HY-W011038S
CAS No.: 143715-91-7
Synonyms: HDPB-d5
Hexadecylpyridinium bromide-d5 (HDPB-d5) is the deuterated form of Hexadecylpyridinium bromide. Hexadecylpyridinium bromide (HDPB) is a cationic surfactant. Hexadecylpyridinium bromide can act as a sensitizer and solubilizer, and is a key component in spectrophotometric determination of metal ion reaction systems. Hexadecylpyridinium bromide can be used as a new passivating ligand for the synthesis and stabilization of cesium lead bromide calcium phosphate nanocrystals.
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Vortioxetine-d8 hydrobromide
Vortioxetine-d8 hydrobromide
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Cat. No.: HY-15414AS
Synonyms: Lu AA21004-d8 hydrobromide
Vortioxetine-d8 (Lu AA 21004-d8) hydrobromide is the deuterated form of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial 5-HT1B agonist (Ki: 15 nM, 33 nM) .
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Perazine-d8
Perazine-d8
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Cat. No.: HY-132494S
CAS No.: 1246815-57-5
Perazine-d8 is a deuterated form of Perazine. Perazine is a potent and orally active antidepressant agent. Perazine has the potential for the research of acute schizophrenics .
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Propoxur-d3
Propoxur-d3
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Cat. No.: HY-B0916S
CAS No.: 1219798-56-7
Propoxur-d3 is the deuterated form of Propoxur (HY-B0916). Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests .
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