MMAF-d8 hydrochloride
Based on 1 Customer Validation
MMAF-d8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.52%
- 分子式: C39H58D8ClN5O8
- 分子量:776.47
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保管条件:
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
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Auristatin |
体外実験
MMAF shows in vitro cytotoxicity against a panel of cell lines. The IC50 values for Karpas 299, H3396, 786-O and Caki-1 are 119, 105, 257, and 200 nM, respectively. Targeted MMAF is much more potent than the free drug, and that cAC10 conjugates of MMAF display pronounced activities. On a molar basis, the cAC10-L1-MMAF4 is an average of over 2200-fold more potent than free MMAF and is active on all the CD30-positive cell lines tested[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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非標識Cas 1415246-68-2
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性状 Solid
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分子量 776.47
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分子式 C39H58D8ClN5O8
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Color White to off-white
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SMILES
O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](C)[C@@H](OC)[C@H]2N(C(C[C@@H](OC)[C@@H](N(C)C([C@@]([2H])(NC([C@@H](NC)C(C)C)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)[C@@H](C)CC)=O)CCC2)=O.Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (128.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2879 mL | 6.4394 mL | 12.8788 mL | 32.1970 mL |
| 5 mM | 0.2576 mL | 1.2879 mL | 2.5758 mL | 6.4394 mL | |
| 10 mM | 0.1288 mL | 0.6439 mL | 1.2879 mL | 3.2197 mL | |
| 15 mM | 0.0859 mL | 0.4293 mL | 0.8586 mL | 2.1465 mL | |
| 20 mM | 0.0644 mL | 0.3220 mL | 0.6439 mL | 1.6098 mL | |
| 25 mM | 0.0515 mL | 0.2576 mL | 0.5152 mL | 1.2879 mL | |
| 30 mM | 0.0429 mL | 0.2146 mL | 0.4293 mL | 1.0732 mL | |
| 40 mM | 0.0322 mL | 0.1610 mL | 0.3220 mL | 0.8049 mL | |
| 50 mM | 0.0258 mL | 0.1288 mL | 0.2576 mL | 0.6439 mL | |
| 60 mM | 0.0215 mL | 0.1073 mL | 0.2146 mL | 0.5366 mL | |
| 80 mM | 0.0161 mL | 0.0805 mL | 0.1610 mL | 0.4025 mL | |
| 100 mM | 0.0129 mL | 0.0644 mL | 0.1288 mL | 0.3220 mL |
MMAF-d8 hydrochloride 関連分類
HY-15579AS 関連分類
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