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MMAF Hydrochloride

HY-15579A

(Monomethylauristatin F Hydrochloride)

MMAF Hydrochloride

MMAF Hydrochloride Chemical Structure

Monomethylauristatin F Hcl(MMAF Hcl) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody drug cytotoxin.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $372 In-stock
2 mg $150 In-stock
5 mg $280 In-stock
10 mg $440 In-stock
50 mg Get quote
100 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €365 In-stock
2 mg €147 In-stock
5 mg €274 In-stock
10 mg €431 In-stock
50 mg Get quote
100 mg Get quote

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Inquiry Information
Product name: MMAF Hydrochloride
Cat. No.: HY-15579A

MMAF Hydrochloride Data Sheet

  • View current batch:

    Purity: 99.38%

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of MMAF Hydrochloride

Monomethylauristatin F Hcl(MMAF Hcl) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody drug cytotoxin.
IC50 value:
Target: tubulin; ADCs cytotoxin
MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself.  MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.

Chemical Information

M.Wt 768.42 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₃₉H₆₆ClN₅O₈
CAS No 1415246-68-2
Solvent & Solubility

DMSO: 27 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.3014 mL 6.5069 mL 13.0137 mL
5 mM 0.2603 mL 1.3014 mL 2.6027 mL
10 mM 0.1301 mL 0.6507 mL 1.3014 mL

References on MMAF Hydrochloride

Other Forms

  • MMAF

    CAS No.: 745017-94-1 Get quote

  • MMAF-OMe

    CAS No.: 863971-12-4 In-stock

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