1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    ADC Cytotoxin
  3. MMAF sodium

MMAF sodium (Synonyms: Monomethylauristatin F sodium)

Cat. No.: HY-15579B Purity: 99.73%
Handling Instructions

MMAF sodium (Monomethylauristatin F sodium) is an antitubulin agent that inhibit cell division; attenuates its cytotoxic activity compared to MMAE. MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

For research use only. We do not sell to patients.

MMAF sodium Chemical Structure

MMAF sodium Chemical Structure

CAS No. : 1799706-65-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 438 In-stock
Estimated Time of Arrival: December 31
2 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 336 In-stock
Estimated Time of Arrival: December 31
10 mg USD 528 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of MMAF sodium:

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Description

MMAF sodium (Monomethylauristatin F sodium) is an antitubulin agent that inhibit cell division; attenuates its cytotoxic activity compared to MMAE. MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

In Vitro

MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay.

Molecular Weight

753.94

Formula

C₃₉H₆₄N₅NaO₈

CAS No.

1799706-65-2

SMILES

CC[[email protected]](C)[[email protected]@H]([[email protected]@H](CC(N1[[email protected]@H](CCC1)[[email protected]@H]([[email protected]@H](C)C(N[[email protected]](C([O-])=O)CC2=CC=CC=C2)=O)OC)=O)OC)N(C([[email protected]](C(C)C)NC([[email protected]](C(C)C)NC)=O)=O)C.[Na+]

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 200 mg/mL (265.27 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3264 mL 6.6318 mL 13.2637 mL
5 mM 0.2653 mL 1.3264 mL 2.6527 mL
10 mM 0.1326 mL 0.6632 mL 1.3264 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (6.63 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (6.63 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (6.63 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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MMAF sodium
Cat. No.:
HY-15579B
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