DL-Dithiothreitol-d6
Based on 1 Customer Validation
DL-Dithiothreitol-d6 is the deuterated form of DL-Dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond.
For research use only. We do not sell to patients.
- Purity: 98.73%
- CAS No.: 850153-85-4
- Formula: C4H4D6O2S2
- Molecular Weight:160.29
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 850153-85-4
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Unlabeled Cas 3483-12-3
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Appearance Solid
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Molecular Weight 160.29
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Formula C4H4D6O2S2
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Color White to off-white
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SMILES
SC([2H])([2H])[C@](O)([2H])[C@@](O)([2H])C([2H])([2H])S
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Synonyms
DTT-d6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (623.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Yao H, et al. Establishment of disulfidptosis-related LncRNA signature as biomarkers in colon adenocarcinoma[J]. Cancer Cell International, 2024, 24(1): 183. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.2387 mL | 31.1935 mL | 62.3869 mL | 155.9673 mL |
| 5 mM | 1.2477 mL | 6.2387 mL | 12.4774 mL | 31.1935 mL | |
| 10 mM | 0.6239 mL | 3.1193 mL | 6.2387 mL | 15.5967 mL | |
| 15 mM | 0.4159 mL | 2.0796 mL | 4.1591 mL | 10.3978 mL | |
| 20 mM | 0.3119 mL | 1.5597 mL | 3.1193 mL | 7.7984 mL | |
| 25 mM | 0.2495 mL | 1.2477 mL | 2.4955 mL | 6.2387 mL | |
| 30 mM | 0.2080 mL | 1.0398 mL | 2.0796 mL | 5.1989 mL | |
| 40 mM | 0.1560 mL | 0.7798 mL | 1.5597 mL | 3.8992 mL | |
| 50 mM | 0.1248 mL | 0.6239 mL | 1.2477 mL | 3.1193 mL | |
| 60 mM | 0.1040 mL | 0.5199 mL | 1.0398 mL | 2.5995 mL | |
| 80 mM | 0.0780 mL | 0.3899 mL | 0.7798 mL | 1.9496 mL | |
| 100 mM | 0.0624 mL | 0.3119 mL | 0.6239 mL | 1.5597 mL |
DL-Dithiothreitol-d6 Related Classifications
HY-15917S2 Related Classifications
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