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Results for "

fluorescence anisotropy

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Fluorescent Dyes

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0077
    2',7'-Difluorofluorescein

    Oregon green 488

    		 Fluorescent Dye Others
    2',7'-Difluorofluorescein (Oregon green 488) is a fluorescein derivative and a pH-sensitive fluorescent probe (pKa ~4.7). Upon excitation at 488 nm, 2',7'-Difluorofluorescein exhibits pH-sensitive fluorescence intensity through the formation of dianions, while its pH sensitivity decreases under excitation at 450 nm, allowing its use in ratiometric pH analysis. 2',7'-Difluorofluorescein can be used for the quantitative analysis of pH values in the range of 2-7 in submicron aerosol particles. 2',7'-Difluorofluorescein undergoes buffer-mediated and buffer-free excited-state proton transfer between different protonated forms, and its cationic form undergoes rapid excited-state deprotonation. 2',7'-Difluorofluorescein is resistant to photodegradation, maintains stable absorption and fluorescence properties within the physiological pH range, and serves as a fluorescent protein label, a component of Ca 2+ indicators, a fluorescent imaging agent, and an anisotropy probe .
    2',7'-Difluorofluorescein
  • HY-117468
    Lissamine rhodamine B
    5+ Cited Publications

    		 Fluorescent Dye Others
    Lissamine rhodamine B is a red-fluorescent dye, it is a derivative of rhodamine. Lissamine rhodamine B can be used as a fluorescent probe to develop competitive aptamer fluorescence anisotropy/polarization (FA/FP) assays .
    Lissamine rhodamine B
  • HY-117401
    5-Dodecanoylaminofluorescein

    		Fluorescent Dye Others
    5-Dodecanoylaminofluorescein is an amphipathic (amphoteric) fluorescent probe (Ex/Em = 485 nm/515-535 nm), which consists of a hydrophilic fluorescein core and a hydrophobic dodecanoyl group (C12 fatty acid chain) linked by an amide bond. 5-Dodecanoylaminofluorescein is mainly used as an interface-localized radical trapping/indicator probe. Dodecanoylaminofluorescein can be used for the determination of the antioxidant properties of emulsions, or can serve as a lipophilic drug model for the study of passive skin penetration when encapsulated in tyrosine-derived nanospheres .
    5-Dodecanoylaminofluorescein
  • HY-134977
    Atrovastatin-PEG3-FITC

    		Ras Cancer
    Atrovastatin-PEG3-FITC (compound S31) is a KRAS-PDEδ interaction inhibitor. Atrovastatin-PEG3-FITC acts as a ligand in fluorescence anisotropy assay .
    Atrovastatin-PEG3-FITC
  • HY-171458
    U-104067

    		Fluorescent Dye Others
    U-104067 can be used as a molecular probe to observe and to quantitate a variety of physical phenomena, such as transfer into lipid membranes, partitioning between surface phases, and partitioning between lipid carriers and target membranes. U-104067 is a sensitive reporter of the tilt/ripple phase transition, monitored by its fluorescence anisotropy and quantum yield changes .
    U-104067
  • HY-D3404
    BODi-1

    		DNA Stain Others
    BODi-1 is a fluorescent modulator targeting dsDNA, which binds to dsDNA via a bis-intercalation mechanism (Ex=465 nm, Em=490 nm). BODi-1 exhibits a fluorescence enhancement effect upon binding to nucleic acids, but its fluorescence intensity, anisotropy and average lifetime decrease at higher dye/DNA ratios. When BODi-1 binds to DNA in liposome complexes, it also shows red-shifted emission spectra, along with reduced quantum yield and average lifetime. BODi-1 does not induce significant DNA conformational changes when the dye/DNA ratio is below 0.01. BODi-1 can be used as a fluorescent probe for the characterization of liposome complexes and FRET studies at this ratio .
    BODi-1
  • HY-171537
    TIM-3-ligand-1

    		Tim3 Inflammation/Immunology
    TIM-3-ligand-1 (Compound 35) is a highly efficient and selective TIM-3 ligand with a Ki value of 156 nM. TIM-3-ligand-1 can be used for research in immunotherapy .
    TIM-3-ligand-1
  • HY-179706
    VS3

    		YAP Cancer
    VS3 is a YAP-TEAD interaction inhibitor. VS3 directly disrupts the interaction between YAP-TEAD by binding to TEAD4 Interface 3 (Kd = 6 μM) on the surface. VS3 exhibits anti-proliferative activity against HT29, HCT116, and A2780. VS3 can be used for research on colorectal adenocarcinoma and ovarian cancer .
    VS3

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