![N-[[P(S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester](https://file.medchemexpress.com/product_pic/hy-184783.gif "Click to View N-[[P(S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester Product Detail")
Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
genotype 1b HCV infections
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "genotype 1b HCV infections" in MCE Product Catalog:
12
12 Publications Verification
Cat. No.: HY-N6798
CAS No.: 35891-70-4
Synonyms: Thermozymocidin; ISP-I
Target:
3
3 Cited Publications
Target:
Research Areas:
VCH-916 is a thiophene derivative and non-nucleoside inhibitor of HCV NS5B polymerase. VCH-916 binds to Thumb Site II. VCH-916 can be used for the research of hepatitis c virus (hcv) infection .
Cat. No.: HY-19840
CAS No.: 1535212-07-7
Synonyms: GS-9857
Target:
Voxilaprevir (GS-9857) is a noncovalent, reversible inhibitor of HCV NS3/4A protease inhibitor (PI) with pangenotypic antiviral activity . Voxilaprevir inhibits genotype 1b and 3a wild-type NS3 proteases with Ki values of 0.038 nM and 0.066 nM, respectively . Voxilaprevir is an orally active direct-acting antiviral agent (DAA) and can be used for HCV infection research .
Cat. No.: HY-10242
CAS No.: 300832-84-2
Synonyms: BILN 2061; BILN 2061ZW
Target:
Research Areas:
Ciluprevir (BILN 2061; BILN 2061ZW) is an orally active macrocyclic peptide inhibitor of hepatitis C virus (HCV)NS3 protease, with an IC50 of 3 nM. Ciluprevir has Kᵢ values of 0.66 nM and 0.30 nM against genotypes 1b and 1a, respectively. Ciluprevir inhibits HCV RNA replication with an EC50 of 1.2 nM, and its EC50 values against genotypes 1b and 1a are 3 nM and 4 nM, respectively. Ciluprevir shows no significant inhibition against human leukocyte elastase and hepatic cathepsin B. Ciluprevir can be used for genotype 1 HCV infection .
Synonyms: BI 201335
Target:
Research Areas:
Faldaprevir (BI 201335) is a potent, orally active and selective noncovalent inhibitor of NS3/4A protease of HCV (hepatitis C virus) genotypes 1a and 1b, with Ki values of 2.6 and 2.0 nM, respectively. Faldaprevir inhibits HCV RNA replication, with EC50 values of 6.5 and 3.1 nM, respectively. Faldaprevir has potent antiviral activity against chronic HCV infection .
Synonyms: Emitasvir diphosphate; DAG-181 diphosphate
Yimitasvir diphosphate (Emitasvir diphosphate; DAG-181 diphosphate) is an orally active inhibitor of hepatitis C virus (HCV) nonstructural protein 5A (NS5A). Yimitasvir diphosphate is applicable to research related to HCV infection .
Cat. No.: HY-147358A
CAS No.: 1959593-23-7
Synonyms: Emitasvir; DAG-181
Yimitasvir (Emitasvir; DAG-181) is an orally active inhibitor of hepatitis C virus (HCV) nonstructural protein 5A (NS5A). Yimitasvir is applicable to research related to HCV infection .
Cat. No.: HY-102030
CAS No.: 1431328-92-5
BMS-961955 is an orally active inhibitor of HCV NS5B polymerase. BMS-961955 exhibits potent inhibitory activity against HCV genotype 1 (GT-1a/1b) replicons with EC50s of 4.3 nM and 7.9 nM, respectively. BMS-961955 can be used for the study of HCV infection .
Cat. No.: HY-19557
CAS No.: 1251165-81-7
Target:
Research Areas:
IDX-320 is a Pipecolic acid (HY-Y0669) derivative. IDX-320 inhibits NS3/4a proteases across genotypes 1a, 1b, 2a, and 4a with an IC50 0.8-1.9 nM. IDX-320 can be used in the research of HCV infection .
Cat. No.: HY-15256A
CAS No.: 1215856-44-2
Synonyms: BI 201335 sodium
Target:
Research Areas:
Faldaprevir sodium is a potent, orally active and selective noncovalent inhibitor of NS3/4A protease of HCV (hepatitis C virus) genotypes 1a and 1b, with Ki values of 2.6 and 2.0 nM, respectively. Faldaprevir sodium inhibits HCV RNA replication, with EC50 values of 6.5 and 3.1 nM, respectively. Faldaprevir sodium has potent antiviral activity against chronic HCV infection .
Cat. No.: HY-N6798R
CAS No.: 35891-70-4
Synonyms: Thermozymocidin (Standard); ISP-I (Standard)
Category:
Target:
Cat. No.: HY-19932
CAS No.: 1193902-95-2
Target:
Research Areas:
MK-2748 is a hepatitis C virus (HCV) NS3/4a protease inhibitor. MK-2748 exhibits broad-spectrum and potent antiviral activity, with nanomolar-level activity against all genotypes (gt1a-gt6) (IC₅₀ < 0.115 nM), showing only slightly weaker activity against gt3a (1.212 nM), and maintaining high inhibitory activity against drug-resistant mutant strains such as gt1b R155K (IC₅₀ = 0.032 nM) and D168Y (IC₅₀ = 0.057 nM). MK-2748 can be used in the research of HCV infection .
Cat. No.: HY-184783
CAS No.: 1631170-16-5
Target:
Research Areas:
N-[[P (S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester is a 5'(S)-C-methyl phosphoramidate prodrug of 2',5'-C-dimethyluridine, as well as a HCV inhibitor. N-[[P (S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester induces anti-HCV activity in HCV genotype 1b replicons with extremely low cytotoxicity. N-[[P (S)]-2'-C-Methyl-P-phenyl-5'-uridylyl]-L-Ala-1-methylethyl ester can be used in studies related to HCV infection .
Cat. No.: HY-13465A
CAS No.: 914778-92-0
Target:
Research Areas:
VCH-916 free base is a thiophene derivative and non-nucleoside inhibitor of HCV NS5B polymerase. VCH-916 free base binds to Thumb Site II. VCH-916 free base can be used for the research of hepatitis c virus (hcv) infection .
Cat. No.: HY-10246A
CAS No.: 847440-99-7
Target:
Research Areas:
A-837093 sodium is a potent and orally active inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase. A-837093 sodium shows potencies against polymerases derived from both HCV genotypes 1a (IC50 = 1.25 nM) and 1b (IC50 = 0.33 nM). A-837093 sodium exhibits antiviral efficacy in HCV-infected chimpanzees. A-837093 sodium can be used for HCV infection research .
Cat. No.: HY-187164
CAS No.: 78945-99-0
Target:
Research Areas:
HCV NS5B polymerase-IN-5 is a HCV NS5B polymerase inhibitor with an IC50 value of 47.9 μM. HCV NS5B polymerase-IN-5 reduces the production of inorganic pyrophosphate and decreases the nucleoside triphosphate incorporation of HCV NS5B polymerase. HCV NS5B polymerase-IN-5 can be used in studies related to hepatitis C virus infection .
Cat. No.: HY-182679
CAS No.: 2085271-43-6
L0909 is an HCV inhibitor with an EC50 of 0.022 μM. L0909 blocks HCV replication by inhibiting E1-mediated viral entry. L0909 exhibits sensitivity to clinical resistant HCV mutants. L0909 displays synergistic effects with clinical HCV drugs. L0909 can be used for the research of hepatitis c virus (HCV) infection .
Cat. No.: HY-16342
CAS No.: 827034-92-4
Target:
Research Areas:
NA808 is an Serine Palmitoyltransferase (SPT) inhibitor. NA808 reduces sphingomyelin synthesis, inhibits its activation in hepatic stellate cells, and decreases the expression of α-SMA protein and mRNA, as well as collagen 1A1 mRNA (IC50 0.16, 0.12, and 0.11 μM, respectively). NA808 inhibits HCV replication and reduces NS3 and RdRp protein expression in HCV replicon cells without significant cytotoxicity and exhibits almost no immunosuppressive effect at effective concentrations. NA808 demonstrates broad-spectrum antiviral activity in humanized chimeric liver mice infected with various HCV genotypes, and dose-dependently reduces serum and hepatic HCV RNA levels. NA808 can be used for research on non-alcoholic steatohepatitis and hepatitis C virus infection .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
