A-837093 sodium
A-837093 sodium is a potent and orally active inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase. A-837093 sodium shows potencies against polymerases derived from both HCV genotypes 1a (IC50 = 1.25 nM) and 1b (IC50 = 0.33 nM). A-837093 sodium exhibits antiviral efficacy in HCV-infected chimpanzees. A-837093 sodium can be used for HCV infection research.
For research use only. We do not sell to patients.
- CAS No.: 847440-99-7
- Formula: C24H26N3NaO6S2
- Molecular Weight:539.60
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All DNA/RNA Synthesis Isoforms
More
Biological Activity
|
NS5B Polymerase |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | EC50 |
11 nM
Compound: 25a
|
Antiviral activity against HCV 1a containing chimeric genotype 1a-H77/1b-con1 subgenom in human Huh7 cells assessed as reduction in viral RNA after 7 days by RT-PCR
Antiviral activity against HCV 1a containing chimeric genotype 1a-H77/1b-con1 subgenom in human Huh7 cells assessed as reduction in viral RNA after 7 days by RT-PCR
|
[PMID: 19226162] |
| Huh-7 | EC50 |
3 nM
Compound: 25a
|
Antiviral activity against HCV isolate Con1 in human Huh7 cells assessed as reduction in viral RNA after 7 days by RT-PCR
Antiviral activity against HCV isolate Con1 in human Huh7 cells assessed as reduction in viral RNA after 7 days by RT-PCR
|
[PMID: 19226162] |
Chemical Information
-
CAS No. 847440-99-7
-
Molecular Weight 539.60
-
Formula C24H26N3NaO6S2
-
SMILES
O=C1C(C(NC2=CC=C(NS(C)(=O)=O)C=C23)=NS3(=O)=O)=C(C4=CC=CC=C4[C@@]1(C)CCC(C)C)O[Na]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)