1. Metabolic Enzyme/Protease
  2. HCV Protease
  3. Voxilaprevir

Voxilaprevir (Synonyms: GS-9857)

Cat. No.: HY-19840
Handling Instructions

Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs).

For research use only. We do not sell to patients.

Voxilaprevir Chemical Structure

Voxilaprevir Chemical Structure

CAS No. : 1535212-07-7

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Description

Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs)[1][2].

IC50 & Target

Hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease[1]

Clinical Trial
Molecular Weight

868.93

Formula

C₄₀H₅₂F₄N₆O₉S

CAS No.

1535212-07-7

SMILES

O=C([[email protected]]1N(C([[email protected]@H](NC(O[[email protected]]2[[email protected]]3C2)=O)C(C)(C)C)=O)C[[email protected]@](OC4=NC5=CC(OC)=CC=C5N=C4C(F)(CCCC3)F)([H])[[email protected]]1CC)N[[email protected]]6([[email protected]](C(F)F)C6)C(NS(=O)(C7(CC7)C)=O)=O

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Voxilaprevir
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