1. Anti-infection
    Metabolic Enzyme/Protease
  2. HCV Protease
  3. Voxilaprevir

Voxilaprevir (Synonyms: GS-9857)

Cat. No.: HY-19840 Purity: 99.17%
Handling Instructions

Voxilaprevir (GS-9857) is a noncovalent, reversible inhibitor of HCV NS3/4A protease inhibitor (PI) with pangenotypic antiviral activity. Voxilaprevir inhibits genotype 1b and 3a wild-type NS3 proteases with Ki values of 0.038 nM and 0.066 nM, respectively. Voxilaprevir is an orally active direct-acting antiviral agent (DAA) and can be used for HCV infection research.

For research use only. We do not sell to patients.

Voxilaprevir Chemical Structure

Voxilaprevir Chemical Structure

CAS No. : 1535212-07-7

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5 mg USD 600 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Voxilaprevir (GS-9857) is a noncovalent, reversible inhibitor of HCV NS3/4A protease inhibitor (PI) with pangenotypic antiviral activity[1]. Voxilaprevir inhibits genotype 1b and 3a wild-type NS3 proteases with Ki values of 0.038 nM and 0.066 nM, respectively[1]. Voxilaprevir is an orally active direct-acting antiviral agent (DAA) and can be used for HCV infection research[2].

IC50 & Target

Hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease[1]

In Vitro

NS3/4A protease is essential for proteolytic cleavage of the HCV encoded polyprotein (intomature forms of NS3, NS4A, NS4B, NS5A and NS5B proteins) and hence for viral replication[1].
In enzymatic assays using recombinant NS3 protease domains and isogenic NS4A peptide cofactors provided in trans. Voxilaprevir is against HCV genotype 1b and 3a NS3 proteases with Ki values of 0.038 nM and 0.066 nM, respectively[1].
In stable cell lines (Huh-7-Lunet or Huh7-1C cells) expressing renilla luciferase-encoding HCV replicons. Voxilaprevir exhibits potent pangenotypic antiviral activity with EC50 ranging from 0.33 to 6.6 nM across genotypes 1 to 6. Voxilaprevir is against HCV replicon strain DQ314805, H77, Con1, JFH-1, J6,J8 (full length) and HM568433, SA13 (NS3 Chimera) with IC50 values of 0.33 nM, 3.9 nM, 3.3 nM, 3.7 nM, 4.5 nM, 1.8 nM, and 6.6 nM, 1.9 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

868.93

Formula

C₄₀H₅₂F₄N₆O₉S

CAS No.
SMILES

O=C([[email protected]]1N(C([[email protected]@H](NC(O[[email protected]]2[[email protected]]3C2)=O)C(C)(C)C)=O)C[[email protected]@](OC4=NC5=CC(OC)=CC=C5N=C4C(F)(CCCC3)F)([H])[[email protected]]1CC)N[[email protected]]6([[email protected]](C(F)F)C6)C(NS(=O)(C7(CC7)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (115.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1508 mL 5.7542 mL 11.5084 mL
5 mM 0.2302 mL 1.1508 mL 2.3017 mL
10 mM 0.1151 mL 0.5754 mL 1.1508 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

VoxilaprevirGS-9857GS9857GS 9857HCV Proteasedirect-acting antiviralDAAHCVinfectionpangenotypicantiviralInhibitorinhibitorinhibit

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Product Name:
Voxilaprevir
Cat. No.:
HY-19840
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