BMS-986144
BMS-986144 is an orally active inhibitor of HCV NS3/4A protease. BMS-986144 binds to the active site of HCV NS3/4A protease and induces conformational changes in the protease. BMS-986144 reduces time-dependent CYP3A4 inhibition, exhibits hepatic microsomal metabolic stability, and undergoes oxidation of the macrocyclic linker chain. BMS-986144 can be used in studies related to hepatitis C virus infection.
For research use only. We do not sell to patients.
- CAS No.: 1606150-08-6
- Formula: C40H48D3F4N5O9S
- Molecular Weight:856.94
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
25 μM
Compound: 21; BMS-986144
|
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
|
[PMID: 33226226] |
| MT2 | CC50 |
34 μM
Compound: 21; BMS-986144
|
Cytotoxicity against human MT2 cells assessed as reduction in cell viability
Cytotoxicity against human MT2 cells assessed as reduction in cell viability
|
[PMID: 33226226] |
BMS-986144 (compound 21) form inhibits GT-3a (S52) HCV NS3/4A protease with an IC50 of 4.8 nM, and suppresses HCV replication across pan-genotypic and drug-resistant replicon cell lines with EC50 values ranging from 0.7 nM (GT-1b) to 12 nM (GT-3a)[1].
BMS-986144 (0.002-40 μM; 0 and 30 min preincubation) presents attenuated time-dependent inhibitory activity toward CYP3A4[1].
BMS-986144 displays in vitro cytotoxicity against Huh7 and MT2 cell lines, with CC50 values of 25 μM and 34 μM respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 1606150-08-6
-
Unlabeled Cas 1410114-25-8
-
Molecular Weight 856.94
-
Formula C40H48D3F4N5O9S
-
SMILES
O=C([C@H]1N2C[C@@H](C1)OC3=NC=CC4=C3C=C(C(OC([2H])([2H])[2H])=C4)F)N[C@@]5(C[C@H]5/C=C\CC[C@H](C[C@H]([C@@H](C2=O)NC(OC(C)(C(F)(F)F)C)=O)CC)C)C(NS(C6(CC6)C)(=O)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-986144 Related Classifications
HY-131905S Related Classifications
Powered by Bioz