BMS-986144
BMS-986144 is an orally active inhibitor of HCV NS3/4A protease. BMS-986144 binds to the active site of HCV NS3/4A protease and induces conformational changes in the protease. BMS-986144 reduces time-dependent CYP3A4 inhibition, exhibits hepatic microsomal metabolic stability, and undergoes oxidation of the macrocyclic linker chain. BMS-986144 can be used in studies related to hepatitis C virus infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1606150-08-6
- 分子式: C40H48D3F4N5O9S
- 分子量:856.94
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
25 μM
Compound: 21; BMS-986144
|
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
|
[PMID: 33226226] |
| MT2 | CC50 |
34 μM
Compound: 21; BMS-986144
|
Cytotoxicity against human MT2 cells assessed as reduction in cell viability
Cytotoxicity against human MT2 cells assessed as reduction in cell viability
|
[PMID: 33226226] |
BMS-986144 (compound 21) form inhibits GT-3a (S52) HCV NS3/4A protease with an IC50 of 4.8 nM, and suppresses HCV replication across pan-genotypic and drug-resistant replicon cell lines with EC50 values ranging from 0.7 nM (GT-1b) to 12 nM (GT-3a)[1].
BMS-986144 (0.002-40 μM; 0 and 30 min preincubation) presents attenuated time-dependent inhibitory activity toward CYP3A4[1].
BMS-986144 displays in vitro cytotoxicity against Huh7 and MT2 cell lines, with CC50 values of 25 μM and 34 μM respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
-
CAS 番号 1606150-08-6
-
非標識Cas 1410114-25-8
-
分子量 856.94
-
分子式 C40H48D3F4N5O9S
-
SMILES
O=C([C@H]1N2C[C@@H](C1)OC3=NC=CC4=C3C=C(C(OC([2H])([2H])[2H])=C4)F)N[C@@]5(C[C@H]5/C=C\CC[C@H](C[C@H]([C@@H](C2=O)NC(OC(C)(C(F)(F)F)C)=O)CC)C)C(NS(C6(CC6)C)(=O)=O)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BMS-986144 関連分類
HY-131905S 関連分類
Powered by Bioz