1410114-25-8
Chemical Structure
BMS-986144 (non-deuterated)
- CAS No.: 1410114-25-8
- Formula:C40H51F4N5O9S
- Molecular Weight:853.92
InChIKey: IJNUZTYJYYUXSD-SMNGPBTOSA-N
SMILES: O=C(OC(C)(C)C(F)(F)F)N[C@H]1[C@H](CC)C[C@H](C)CC/C=C\[C@@]2([H])[C@](C2)(C(NS(=O)(C3(C)CC3)=O)=O)NC([C@@](C[C@@H](OC4=NC=CC5=C4C=C(F)C(OC)=C5)C6)([H])N6C1=O)=O
Biological Activity: BMS-986144 non-deuterated is the non-tritium form of BMS-986144 (HY-131905S). BMS-986144 non-deuterated is an orally active inhibitor of HCV NS3/4A protease. BMS-986144 non-deuterated binds to the active site of HCV NS3/4A protease and induces conformational changes in the protease. BMS-986144 non-deuterated reduces time-dependent CYP3A4 inhibition, exhibits hepatic microsomal metabolic stability, and undergoes oxidation of the macrocyclic linker chain. BMS-986144 non-deuterated can be used in studies related to hepatitis C virus infection[1].
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BMS-986144 (non-deuterated) | BMS-986144 non-deuterated is the non-tritium form of BMS-986144 (HY-131905S). BMS-986144 non-deuterated is an orally active inhibitor of HCV NS3/4A protease. BMS-986144 non-deuterated binds to the active site of HCV NS3/4A protease and induces conformational changes in the protease. BMS-986144 non-deuterated reduces time-dependent CYP3A4 inhibition, exhibits hepatic microsomal metabolic stability, and undergoes oxidation of the macrocyclic linker chain. BMS-986144 non-deuterated can be used in studies related to hepatitis C virus infection. | |||||||||||||||||||||
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BMS-986144 | BMS-986144 is an orally active inhibitor of HCV NS3/4A protease. BMS-986144 binds to the active site of HCV NS3/4A protease and induces conformational changes in the protease. BMS-986144 reduces time-dependent CYP3A4 inhibition, exhibits hepatic microsomal metabolic stability, and undergoes oxidation of the macrocyclic linker chain. BMS-986144 can be used in studies related to hepatitis C virus infection. | |||||||||||||||||||||
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