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Art. -Nr.: HY-19557

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IDX-320

IDX-320 is a Pipecolic acid (HY-Y0669) derivative. IDX-320 inhibits NS3/4a proteases across genotypes 1a, 1b, 2a, and 4a with an IC₅₀ 0.8-1.9 nM. IDX-320 can be used in the research of HCV infection.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1251165-81-7
Formel: C₃₇H₄₃F₃N₆O₇S₂
Molecular Weight:804.90

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

IDX-320 Chemical Structure

CAS. Nr.: 1251165-81-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC₅₀: 0.8-1.9 nM (NS3/4a proteases across genotypes 1a, 1b, 2a, and 4a)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	CC₅₀	>10 μM Compound: 8; IDX320	Cytotoxicity against human hepatocytes Cytotoxicity against human hepatocytes	[PMID: 26410074]
Huh-7	CC₅₀	52.78 μM Compound: 8; IDX320	Cytotoxicity against human HuH7 cells by colorimetric proliferation assay Cytotoxicity against human HuH7 cells by colorimetric proliferation assay	[PMID: 26410074]
Huh-7	EC₅₀	0.7 nM Compound: 8; IDX320	Antiviral activity against HCV genotype 1b infected in human HuH7 cells after 3 days by luciferase assay Antiviral activity against HCV genotype 1b infected in human HuH7 cells after 3 days by luciferase assay	[PMID: 26410074]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 1251165-81-7
Molecular Weight 804.90
Formel C₃₇H₄₃F₃N₆O₇S₂
SMILES

O=C(NS(=O)(C1(CC1)C)=O)[C@]23NC([C@@](C[C@@H](OC4=CC(C5=NC(C(F)(F)F)=CS5)=NC6=C(C)C(OC)=CC=C46)CC7)([H])N7C(N(C)CCCC/C=C\[C@]2([H])C3)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liverton N J. Evolution of HCV NS3/4a Protease Inhibitors[M]//HCV: The Journey from Discovery to a Cure: Volume I. Cham: Springer International Publishing, 2019: 231-259.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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