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Results for "

heat+shock+factor+1

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

2

Natural
Products

2

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19356
    Rocaglamide
    25+ Cited Publications

    Roc-A

    		 NF-κB HSP Eukaryotic Initiation Factor (eIF) Inflammation/Immunology Cancer
    Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia [1] .
    Rocaglamide
  • HY-100872
    KRIBB11
    15+ Cited Publications

    		 HSP Apoptosis Cancer
    KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 μM.
    KRIBB11
  • HY-138280
    DTHIB
    5+ Cited Publications

    		 HSP Cancer
    DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1. DTHIB has potently anticancer activities and can be used for prostate cancer research [1].
    DTHIB
  • HY-145927
    NXP800
    3 Publications Verification

    CCT361814

    		 HSP Cancer
    NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research [1] .
    NXP800
  • HY-144867
    CCT245232

    		HSP Cancer
    CCT245232 is a potent inhibitor of heat shock factor 1 (HSF1). HSF1 is the master regulator of the heat shock response, in which multiple genes are induced in response to temperature increase and other stresses. CCT245232 has the potential for the research of proliferative diseases, such as cancer (extracted from patent WO2015049535A1) [1].
    CCT245232
  • HY-19356B
    (+)-Rocaglamide

    		Drug Derivative NF-κB HSP Eukaryotic Initiation Factor (eIF) Inflammation/Immunology Cancer
    (+)-Rocaglamide is the dextrorotatory enantiomer of Rocaglamide (HY-19356). Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of 50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia [1] .
    (+)-Rocaglamide
  • HY-100872R
    KRIBB11 (Standard)

    		HSP Reference Standards Apoptosis Cancer
    KRIBB11 (Standard) is the analytical standard of KRIBB11 (HY-100872). This product is intended for research and analytical applications. KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 μM.
    KRIBB11 (Standard)
  • HY-N17756
    Withanolide D

    		HSP Cancer
    Withanolide D (Compound 2) is a steroidal ester found in Withania somnifera (L.) Dunal, with anticancer activity. Withanolide D can activate the heat-shock factor 1 (HSF1)-dependent stress response. Withanolide D can be used for the research of cancer such as lymphoma [1].
    Withanolide D
  • HY-167961
    HSF1-IN-1

    		HSP Cancer
    HSF1-IN-1 (page 71, compound 1) is a heat shock factor 1 (HSF1) inhibitor. HSF1-IN-1 inhibit stress-induced expression from heat shock gene promoters. HSF1-IN-1 can be used for the study of cancer [1].
    HSF1-IN-1

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