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Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

hematopoietic protein tyrosine phosphatase

" in MedChemExpress (MCE) Product Catalog:

標的別:	Phosphatase (4) Apoptosis (2) DNA/RNA Synthesis (1) MDM-2/p53 (1) Parasite (1) STAT (1)
研究分野別:	Cancer (3) Infection (1) Inflammation/Immunology (2) Neurological Disease (1)

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Targets Recommended: Phosphatase Btk Syk SHP2 PhosTACs PTEN Pyk2 TNK1 Tyrosine Hydroxylase DYRK BRK FAK SHP1 FLT3 Anaplastic lymphoma kinase (ALK)

製品番号	製品名	Target	研究分野	構造式

HY-133146

DJ001	Phosphatase Apoptosis	Inflammation/Immunology
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor with an IC₅₀ of 1.43 μM. DJ001 displays no inhibitory activity against other phosphatases, with only modest inhibitory activity against Protein Phosphatase 5. DJ001 promotes promote hematopoietic stem cell regeneration .

HY-127178

ML120 analog 1	Phosphatase	Cancer
ML120 analog 1 (compound 1) is a competitive inhibitor with a K_i of 0.69 μM for Hematopoietic protein tyrosine phosphatase (HePTP) .

HY-W414644

Fluacrypyrim	Parasite STAT Phosphatase MDM-2/p53 Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
Fluacrypyrim, a Miticide, is a STAT3 inhibitor. Fluacrypyrim significantly increases the protein tyrosine phosphatases(PTPs) activity. Fluacrypyrim inhibits the growth of leukemia cells by a predominant G1 arrest with significant decrease of the protein and mRNA levels of cyclin D1. Fluacrypyrim selectively inhibits STAT3 signaling, inducing growth arrest and apoptosis in STAT3-dependent cancer cells. Fluacrypyrim mitigates IR-induced hematopoietic system injury mainly by preventing apoptosis in the HSCs. Fluacrypyrim demonstrates significant analgesic and anti-inflammatory effects by inhibiting uterine smooth muscle contraction and inflammatory responses .

HY-182634

NCGC00063279	DNA/RNA Synthesis Phosphatase	Cancer
NCGC00063279 is a reversible Werner Syndrome Helicase-Nuclease (WRN) helicase inhibitor with modest selectivity over BLM and FANCJ helicases, and does not inhibit WRN exonuclease activity at active concentrations. NCGC00063279 inhibits Hematopoietic Protein Tyrosine Phosphatase (HePTP) and reduces proliferation of cancer cells. NCGC00063279 can be used for the research of osteosarcoma .

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HY-P71141

	SHP-1 Protein, Human (His) 1 Publications Verification tyrosine-protein phosphatase Non-Receptor Type 6; hematopoietic Cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; PTP-1C; protein-tyrosine phosphatase SHP-1; SH-PTP1; PTPN6; HCP; PTP1C	Human	E. coli
	SHP-1 Protein modulates signaling from tyrosine-phosphorylated cell surface receptors, including KIT and EGFR. It enhances the inhibition of mast cell activation via the Lilrb4a receptor. The SH2 regions interact with cellular components to regulate its phosphatase activity. In collaboration with MTUS1, it induces UBE2V2 expression upon angiotensin II stimulation. SHP-1 plays a crucial role in hematopoiesis. SHP-1 Protein, Human (His) is the recombinant human-derived SHP-1 protein, expressed by E. coli , with C-6*His labeled tag.

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Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3)
Application:	IHC-P (2) ICC/IF (2) IP (1) WB (3) FC (2)
Isotype:	IgG (2) IgG2a (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

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HY-P81307A

	SHP1 Antibody (YA1045) PTPN6; HCP; PTP1C; tyrosine-protein phosphatase non-receptor type 6; hematopoietic cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; PTP-1C; protein-tyrosine phosphatase SHP-1; SH-PTP1	WB, IHC-P, ICC/IF, FC	Human
	SHP1 Antibody (YA1045) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SHP1.

HY-P81307

	SHP1 Antibody (YA1044) PTPN6; HCP; PTP1C; tyrosine-protein phosphatase non-receptor type 6; hematopoietic cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; PTP-1C; protein-tyrosine phosphatase SHP-1; SH-PTP1	WB, IP	Human
	SHP1 Antibody (YA1044) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SHP1.

HY-P81307AA

	SHP1 Antibody (YA1045)(PBS only) PTPN6; HCP; PTP1C; tyrosine-protein phosphatase non-receptor type 6; hematopoietic cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; PTP-1C; protein-tyrosine phosphatase SHP-1; SH-PTP1	WB, IHC-P, ICC/IF, FC	Human
	SHP1 Antibody (YA1045) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SHP1.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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