2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. DNA/RNA Synthesis Phosphatase
  4. NCGC00063279

NCGC00063279 is a reversible Werner Syndrome Helicase-Nuclease (WRN) helicase inhibitor with modest selectivity over BLM and FANCJ helicases, and does not inhibit WRN exonuclease activity at active concentrations. NCGC00063279 inhibits Hematopoietic Protein Tyrosine Phosphatase (HePTP) and reduces proliferation of cancer cells. NCGC00063279 can be used for the research of osteosarcoma.

For research use only. We do not sell to patients.

NCGC00063279

NCGC00063279 Chemical Structure

CAS No. : 714932-54-4

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Description

NCGC00063279 is a reversible Werner Syndrome Helicase-Nuclease (WRN) helicase inhibitor with modest selectivity over BLM and FANCJ helicases, and does not inhibit WRN exonuclease activity at active concentrations. NCGC00063279 inhibits Hematopoietic Protein Tyrosine Phosphatase (HePTP) and reduces proliferation of cancer cells. NCGC00063279 can be used for the research of osteosarcoma[1].

In Vitro

NCGC00063279 (1-100 μM; 3 days) at 100 μM reduces U2-OS human osteosarcoma cell proliferation by 40% after 3 days of exposure[1].
NCGC00063279 (50 μM; 3 days) does not inhibit HeLa 1.2.11 human cervical cancer cell proliferation over a 3-day period[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NCGC00063279 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: U2-OS human osteosarcoma cells
Concentration: 1, 10 and 100 μM
Incubation Time: 3 days
Result: Reduced U2-OS cell proliferation by 40% after 3 days of exposure at 100 μM.
Did not significantly affect proliferation at 1 μM and 10 μM concentrations.

Cell Proliferation Assay[1]

Cell Line: HeLa 1.2.11 human cervical cancer cells
Concentration: 50 μM
Incubation Time: 3 days
Result: Did not significantly affect HeLa 1.2.11 cell proliferation on day 0 or day 3, with proliferation remaining at or above control levels.
Molecular Weight

319.31

Formula

C18H13N3O3
CAS No.
SMILES

O=C1NC2=C(C=C1C3=NOC(C4=CC=CC=C4)=N3)C=C(OC)C=C2
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Purity & Documentation
References
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NCGC00063279 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCGC00063279714932-54-4NCGC 00063279NCGC-00063279DNA/RNA SynthesisPhosphataseU2-OS human osteosarcoma cellBLM helicasesHeLa 1.2.11 human cervical cancer cellcancer cellsWRN exonucleaseWerner Syndrome Helicase-Nuclease (WRN) helicaseFANCJ helicasesHematopoietic Protein Tyrosine Phosphatase (HePTP)osteosarcomaInhibitorinhibitorinhibit

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