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NCGC00063279

NCGC00063279 is a reversible Werner Syndrome Helicase-Nuclease (WRN) helicase inhibitor with modest selectivity over BLM and FANCJ helicases, and does not inhibit WRN exonuclease activity at active concentrations. NCGC00063279 inhibits Hematopoietic Protein Tyrosine Phosphatase (HePTP) and reduces proliferation of cancer cells. NCGC00063279 can be used for the research of osteosarcoma.

For research use only. We do not sell to patients.

CAS No.: 714932-54-4
Formula: C₁₈H₁₃N₃O₃
Molecular Weight:319.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NCGC00063279 Chemical Structure

CAS No.: 714932-54-4

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

NCGC00063279 (1-100 μM; 3 days) at 100 μM reduces U2-OS human osteosarcoma cell proliferation by 40% after 3 days of exposure^[1].
NCGC00063279 (50 μM; 3 days) does not inhibit HeLa 1.2.11 human cervical cancer cell proliferation over a 3-day period^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

U2-OS human osteosarcoma cells
Concentration:

1, 10 and 100 μM
Incubation Time:

3 days
Result:

Reduced U2-OS cell proliferation by 40% after 3 days of exposure at 100 μM.
Did not significantly affect proliferation at 1 μM and 10 μM concentrations.

Cell Proliferation Assay^[1]

Cell Line:

HeLa 1.2.11 human cervical cancer cells
Concentration:

50 μM
Incubation Time:

3 days
Result:

Did not significantly affect HeLa 1.2.11 cell proliferation on day 0 or day 3, with proliferation remaining at or above control levels.

Chemical Information

CAS No. 714932-54-4
Molecular Weight 319.31
Formula C₁₈H₁₃N₃O₃
SMILES

O=C1NC2=C(C=C1C3=NOC(C4=CC=CC=C4)=N3)C=C(OC)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sommers JA, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019;14(1):e0210525. Published 2019 Jan 9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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